HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
- CAS No.
- 21416-88-6
- Chemical Name:
- HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
- Synonyms
- Brn 3981691;meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane;meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane;ICRF-193 apoptosis inducer, arabinosidase substrate;2,6-Piperazinedione, 4,4'-(1,2-dimethylethylene)di-, meso-;2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel-;2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)-;2,6-Piperazinedione, 4,4'-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-, rel-
- CBNumber:
- CB1972553
- Molecular Formula:
- C12H18N4O4
- Molecular Weight:
- 282.3
- MDL Number:
- MFCD01702964
- MOL File:
- 21416-88-6.mol
| Density | 1.308 |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: soluble4mg/mL |
| form | Solid |
| color | White to off-white |
| biological source | synthetic (organic) |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352204 |
| NACRES | NA.77 |
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I4659 | ICRF-193 apoptosis inducer, arabinosidase substrate | 21416-88-6 | 1mg | $332 | 2024-03-01 | Buy |
| Sigma-Aldrich | I4659 | ICRF-193 apoptosis inducer, arabinosidase substrate | 21416-88-6 | 5mg | $902 | 2024-03-01 | Buy |
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Chemical Properties,Uses,Production
Uses
ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis.
Definition
ChEBI: ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent.
General Description
ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable?complex.
Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells., ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks.
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Preparation Products And Raw materials
Raw materials
Preparation Products
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Heze Development Zone chuangli Chemical Co., Ltd. | +86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 900 | 55 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9485 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44807 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 30016 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2666 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11183 | 58 |
