Fantofarone
- CAS No.
- 114432-13-2
- Chemical Name:
- Fantofarone
- Synonyms
- CS-2766;SR-33557;Fantofarone;Fantofarone, 10 mM in DMSO;FANTOFARONE;SR-33557;SR33557; 114432-13-2;Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels;2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine;2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[2-(propan-2-yl)indolizin-1-yl]sulfonyl}phenoxy)propyl]amine;3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine;Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-
- CBNumber:
- CB21118032
- Molecular Formula:
- C31H38N2O5S
- Molecular Weight:
- 550.71
- MDL Number:
- MFCD00867144
- MOL File:
- 114432-13-2.mol
| Melting point | 82-83° |
|---|---|
| Density | dz 1.21 g/cm3 |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml |
| form | A crystalline solid |
| pka | 8.34 ± 0.05(at 25℃) |
| color | Light yellow to yellow |
| FDA UNII | KU213XYO69 |
Fantofarone price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26381 | Fantofarone | 114432-13-2 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 26381 | Fantofarone | 114432-13-2 | 25mg | $745 | 2024-03-01 | Buy |
| Cayman Chemical | 26381 | Fantofarone | 114432-13-2 | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 26381 | Fantofarone | 114432-13-2 | 10mg | $321 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0011405 | FANTOFARONE 95.00% | 114432-13-2 | 5MG | $496.39 | 2021-12-16 | Buy |
Fantofarone Chemical Properties,Uses,Production
Uses
Fantofarone is a highly potent Calcium Channel antagonist.
Biological Activity
Fantofarone is a potent antagonist of Calcium Channels.
in vitro
It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites.
in vivo
Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective.
References
[1] Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40. DOI:10.1016/s0006-2952(97)00482-6
[2] Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50. DOI:10.1016/s0006-2952(98)00026-4
Fantofarone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 947 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
View Lastest Price from Fantofarone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Fantofarone
114432-13-2
|
US $31.00-122.00 / mg | 98.36% | 10g | TargetMol Chemicals Inc. |
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- Fantofarone
114432-13-2
- US $31.00-122.00 / mg
- 98.36%
- TargetMol Chemicals Inc.