- Fantofarone
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- $72.00 / 5mg
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2025-04-29
- CAS:114432-13-2
- Min. Order:
- Purity: 98.36%
- Supply Ability: 10g
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| | Fantofarone Basic information |
| Product Name: | Fantofarone | | Synonyms: | Fantofarone;2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine;SR-33557;3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine;FANTOFARONE;SR-33557;SR33557; 114432-13-2;CS-2766;Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-;Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels | | CAS: | 114432-13-2 | | MF: | C31H38N2O5S | | MW: | 550.71 | | EINECS: | | | Product Categories: | API | | Mol File: | 114432-13-2.mol |  |
| | Fantofarone Chemical Properties |
| Melting point | 82-83° | | density | dz 1.21 g/cm3 | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml | | form | A crystalline solid | | pka | 8.34 ± 0.05(at 25℃) | | color | Light yellow to yellow |
| | Fantofarone Usage And Synthesis |
| Uses | Fantofarone is a highly potent Calcium Channel antagonist. | | Biological Activity | Fantofarone is a potent antagonist of Calcium Channels. | | in vitro | It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites. | | in vivo | Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective. | | References | [1] Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40. DOI:10.1016/s0006-2952(97)00482-6
[2] Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50. DOI:10.1016/s0006-2952(98)00026-4 |
| | Fantofarone Preparation Products And Raw materials |
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