泛托法隆
中文名称 | 泛托法隆 |
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中文同义词 | 泛托法隆;3,4-二甲氧基-N-甲基-N- [3-[4-[[2-(1-甲基乙基)-1-氮茚基]磺酰基]苯氧基]丙基]苯乙胺;芬托法隆 |
英文名称 | Fantofarone |
英文同义词 | Fantofarone;2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine;SR-33557;3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine;FANTOFARONE;SR-33557;SR33557; 114432-13-2;CS-2766;Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-;Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels |
CAS号 | 114432-13-2 |
分子式 | C31H38N2O5S |
分子量 | 550.71 |
EINECS号 | |
相关类别 | API |
Mol文件 | 114432-13-2.mol |
结构式 |
泛托法隆 性质
熔点 | 82-83° |
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密度 | dz 1.21 g/cm3 |
储存条件 | Store at -20°C |
溶解度 | DMF:10 mg/ml;二甲基亚砜:10 mg/ml |
形态 | 结晶固体 |
酸度系数(pKa) | 8.34 ± 0.05(at 25℃) |
颜色 | 浅黄至黄色 |
Calcium Channel.
It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites. Interestingly, Fantofarone is ca . 10 times more potent than verapamil. Fantofarone (SR) is 10 times more potent than the phenylalkylamine verapamil (VR) on the two P. fdciparum strains. As revealed by the isobolograms, the two calcium channel blockers potentiate the CQ sensitivity activity on the CQ-resistant P. fufcipurum strain, verapamil appearing 2 to 3 times more potent than Fantofarone. Furthermore, when used at similar subinhibitory fractions of their IC 50 , VR is 2 to 3 times more potent than Fantofarone in decreasing CQ resistance.
Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective. Although it totally inhibits distal AIV, isosorbide dinitrate does not significantly affect proximal diameter decrease. The most potent compound with regard to both the distal and proximal vasospasms is Fantofarone, which significantly reduces AIV throughout the experiment. Verapamil does not reduce AIV significantly.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-105117 | Fantofarone | 1 mg | 400元 | |
2024/08/19 | HY-105117 | 泛托法隆 Fantofarone | 114432-13-2 | 5mg | 900元 |