MRS 2578
- CAS No.
- 711019-86-2
- Chemical Name:
- MRS 2578
- Synonyms
- CS-1109;MRS 2578;MRS-2578; MRS2578;MRS 2578 USP/EP/BP;MRS 2578 >=95% (HPLC);MRS 2578;MRS-2578; MRS2578;MRS2578 P2Y6 antagonist MRS-2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA];1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
- CBNumber:
- CB2112787
- Molecular Formula:
- C20H20N6S4
- Molecular Weight:
- 472.67
- MDL Number:
- MFCD07370141
- MOL File:
- 711019-86-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS06,GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301-H312+H332-H315-H319-H334-H335 | |||||||||
Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 20/21/22-36/37/38-42 | |||||||||
Safety Statements | 22-26-36/37/39-45 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
MRS 2578 price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M0319 | MRS 2578 ≥95% (HPLC) | 711019-86-2 | 5mg | $150 | 2024-03-01 | Buy |
Sigma-Aldrich | M0319 | MRS 2578 ≥95% (HPLC) | 711019-86-2 | 25mg | $572 | 2024-03-01 | Buy |
Cayman Chemical | 19704 | MRS 2578 ≥98% | 711019-86-2 | 5mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 19704 | MRS 2578 ≥98% | 711019-86-2 | 10mg | $78 | 2024-03-01 | Buy |
Cayman Chemical | 19704 | MRS 2578 ≥98% | 711019-86-2 | 25mg | $183 | 2024-03-01 | Buy |
MRS 2578 Chemical Properties,Uses,Production
Description
MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.
Uses
MRS 2578 is a selective P2Y66?receptor antagonist.
Uses
MRS 2578 has been used an antagonist of purinoceptor P2Y6:
- to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
- in P. aeruginosa infected mice to test its effect on the inflammatory responses
- to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes
Biological Activity
Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
Biochem/physiol Actions
MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.
storage
-20°C (desiccate)
References
[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770.
MRS 2578 Preparation Products And Raw materials
Raw materials
Preparation Products
MRS 2578 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24607 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7431 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |