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Benidipine

Benidipine structure

CAS No.: 105979-17-7

Chemical Name:: Benidipine

Synonyms: BENIDIPINE HCL;(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;KW-3049;5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;CONIEL;CAPADIPINE;BENIDIPINE;NACADIPINE;rac Benidipine

CBNumber:: CB2131201

Molecular Formula:: C28H31N3O6

Molecular Weight:: 505.56

MDL Number:: MFCD00906929

MOL File:: 105979-17-7.mol

MSDS File:: SDS

Last updated:2024-10-28 23:16:16

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Benidipine Properties

Boiling point	625.2±55.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
pka	pKa 7.34(H2O(long extrapolation) ) (Uncertain)
Water Solubility	316μg/L at 25℃
LogP	4.61
CAS DataBase Reference	105979-17-7(CAS DataBase Reference)
FDA UNII	4G9T91JS7E
ATC code	C08CA15

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501

Benidipine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B157508	racBenidipine	105979-17-7	0.5mg	$45	2021-12-16	Buy
American Custom Chemicals Corporation	API0002106	CONIEL 95.00%	105979-17-7	100MG	$693	2021-12-16	Buy
Medical Isotopes, Inc.	18512	Benidipine	105979-17-7	25mg	$1500	2021-12-16	Buy
American Custom Chemicals Corporation	API0002106	CONIEL 95.00%	105979-17-7	1G	$1501.5	2021-12-16	Buy
AvaChem	3003B	Benidipine	105979-17-7	100mg	$89	2021-12-16	Buy

Product number	Packaging	Price	Buy
B157508	0.5mg	$45	Buy
API0002106	100MG	$693	Buy
18512	25mg	$1500	Buy
API0002106	1G	$1501.5	Buy
3003B	100mg	$89	Buy

Benidipine Chemical Properties,Uses,Production

Uses

Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

Enzyme inhibitor

This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.

Benidipine Preparation Products And Raw materials

Raw materials

3,5-Pyridinedicarboxylic acid Methyl 3-aminocrotonate Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1-Benzyl-3-piperidinol

Preparation Products

Benidipine Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15354	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9314	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58

Supplier	Advantage
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Shandong chuangyingchemical Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hebei Mojin Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Baoji Guokang Healthchem co.,ltd	58

View Lastest Price from Benidipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-10-28	Benidipine 105979-17-7	US $2785.00-3520.00 / mg			10g	TargetMol Chemicals Inc.
2023-01-31	Benidipine 105979-17-7	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2021-07-13	Benidipine 105979-17-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Benidipine
105979-17-7
US $2785.00-3520.00 / mg
TargetMol Chemicals Inc.

Benidipine
105979-17-7
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Benidipine
105979-17-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

105979-17-7(Benidipine)Related Search:

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2-(Diethylamino)ethyl methacrylate 1-Benzyl-3-piperidinol hydrochloride Nitrendipine

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NACADIPINE BENIDIPINE CAPADIPINE CONIEL 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-(+-)- (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester RAC Benidipine D7 Benidipine USP/EP/BP rac Benidipine (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester (R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel- BENIDIPINE HCL KW-3049 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 105979-17-7 C28H31N3O6HCl Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Pharmaceutical