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tuberostemonine

tuberostemonine structure

CAS No.: 6879-01-2

Chemical Name:: tuberostemonine

Synonyms: Nsc366235;Parathymine;uberostemonine;TuberosteMonin;tuberostemonine;TUBERSTEMONINE(P);Tuberostemonine(P);Tuberostemonine-RM;Tuberostemonine, 98%, from Stemona tuberosa L.;2β-[(2S,4S)-Tetrahydro-4-methyl-5-oxofuran-2-yl]stenine

CBNumber:: CB21372283

Molecular Formula:: C22H33NO4

Molecular Weight:: 375.5

MDL Number:: MFCD11111456

MOL File:: 6879-01-2.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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tuberostemonine Properties

Melting point	86～88℃
Boiling point	554.2±50.0 °C(Predicted)
Density	1.19±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMF:10.0(Max Conc. mg/mL);26.63(Max Conc. mM) DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.88(Max Conc. mM) DMSO:1.0(Max Conc. mg/mL);2.66(Max Conc. mM)
form	A solid
pka	8.90±0.70(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

HS Code

29399990

NFPA 704

	0
2		0

tuberostemonine price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL83300	Tuberostemonine phyproof? Reference Substance	6879-01-2	10MG	$465	2024-03-01	Buy
Usbiological	301087	Tuberostemonine	6879-01-2	20mg	$405	2021-12-16	Buy
TRC	T897125	Tuberostemonine	6879-01-2	5mg	$140	2021-12-16	Buy
Usbiological	468356	Tuberostemonine	6879-01-2	1mg	$312	2021-12-16	Buy
Biorbyt Ltd	orb259541	Tuberostemonine 98%	6879-01-2	20mg	$340	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHL83300	10MG	$465	Buy
301087	20mg	$405	Buy
T897125	5mg	$140	Buy
468356	1mg	$312	Buy
orb259541	20mg	$340	Buy

tuberostemonine Chemical Properties,Uses,Production

Description

This novel alkaloid has been isolated from Sternona sessilifolia and S. tuberosa and was first given the formula C19H29O4N, subsequently altered to that given above. It crystallizes in colourless needles from MeOH with 1 mole of solvent, m.p. 65-88°C (dec.) and has [α]_D - 25.4° (Me2CO). It is a non-phenolic, tertiary base and yields a hydrobromide, m.p. 120°C (dec.) and a perchlorate, m.p. 242°C (dec.). The methiodide monohydrate has m.p. 236-8°C (dec.) and the methochloride, dihydrate, m.p. 172°C. A methosulphate has also been prepared, m.p. 253°C (dec.). The base is not hydrolyzed by acids but in the presence of excess PtO2 it gives the dihydro derivative, m.p. 133°C, furnishing a hydrochloride, m.p. 281 ° C. Oxidation with KMnO4 gives a C17 compound, whereas oxidation with silver oxide forms a neutral substance, C22H29O4N, m.p. 178°C which still contains the lactone groups and gives a positive Ehrlich pyrrole reaction.

Uses

Tuberostemonine is elucidated as one of the major components of Radix Stemonae and has been shown to display therapeutic effects against cigarette smoke-induced acute lung inflammation.

Definition

ChEBI: A natural product found in Stemona phyllantha and Stemona tuberosa.

References

Kondo, Suzuki, Satomi.,J. Pharrn. Soc., Japan, 54,96 (1934)
Kondo, Suzuki, Satomi., ibid, 59, 177 (1939)
Kondo, Suzuki, Satomi., ibid, 60, 149 (1940)
Kondo, Suzuki, Satomi., ibid, 61, 111 (1941)
Kaneko., Ann. Rep. ITSUU Lab. (Tokyo), 11,45 (1960)
Gotz, Bogri, Gray., Tetrahedron Lett., 707 (1961)
Edwards, Feniak, Handa., Can. J. Chern., 40,455,2416 (1962)
Crystal structure: Harada et ai., Chern. Cornrnun., 460 (1967)

tuberostemonine synthesis

Synthesis of tuberostemonine from Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one, 8-ethenyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2S,7aR,8R,8aS,11S,11aS,11bR,11cR)-

tuberostemonine Preparation Products And Raw materials

Raw materials

Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one, 8-ethenyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2S,7aR,8R,8aS,11S,11aS,11bR,11cR)- 1H-Indole-1,2-dicarboxylic acid, 2,3,3a,6,7,7a-hexahydro-6-hydroxy-, 2-methyl 1-(phenylmethyl) ester, [2S-(2α,3aβ,6β,7aα)]- (9CI)

Preparation Products

Furo[2,?3-?h]?pyrrolo[3,?2,?1-?jk]?[1]?benzazepin-?10(4H)?-?one, 8-?ethyl-?5,?6,?7,?7a,?8,?8a,?11,?11a-?octahydro-?11-?methyl-?2-?[(2S,?4S)?-?tetrahydro-?4-?methyl-?5-?oxo-?2-?furanyl]?-?, (7aR,?8R,?8aS,?11S,?11aR)?-

tuberostemonine Suppliers

Global( 158)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58

Supplier	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58
career henan chemical co	58

View Lastest Price from tuberostemonine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Tuberostemonine 6879-01-2	US $47.00-169.00 / mg		99.68%	10g	TargetMol Chemicals Inc.
2024-04-12	tuberostemonine 6879-01-2	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2023-02-24	Tuberstemonine 6879-01-2	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

Tuberostemonine
6879-01-2
US $47.00-169.00 / mg
99.68%
TargetMol Chemicals Inc.

tuberostemonine
6879-01-2
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

Tuberstemonine
6879-01-2
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

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tuberostemonine (7aR,8aβ,11aβ,11bα,11cβ)-2β-[(2S,4S)-Tetrahydro-4-methyl-5-oxofuran-2-yl]-8β-ethyltetradecahydro-11β-methylfuro[2,3-h]pyrrolo[3,2,1-jk][1]benzoazepine-10-one 2β-[(2S,4S)-Tetrahydro-4-methyl-5-oxofuran-2-yl]stenine Nsc366235 TUBERSTEMONINE(P) TuberosteMonin Tuberostemonine, 98%, from Stemona tuberosa L. Parathymine Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one, 8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2S,7aR,8R,8aS,11S,11aS,11bR,11cR)- uberostemonine (2S,31R,7AR,8R,8aS,11S,11aS,11bR)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one NADP+,Parasite,Tuberostemonine,Inhibitor,antimalarial,pfFNR,reductases,falciparum,inhibit,Plasmodium,ferredoxin Tuberostemonine(P) Tuberostemonine-RM 6879-01-2 6789-01-2 6979-01-2 6878-01-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract