SANT-1
- CAS No.
- 304909-07-7
- Chemical Name:
- SANT-1
- Synonyms
- SANT-1;CS-1685;SANT1 10MG;SANT1;SANT 1;SANT-1 USP/EP/BP;SANT-1; SANT1;SANT 1;SANT-1, 10 mM in DMSO;SANT-1 - CAS 304909-07-7 - Calbiochem;SANT-1 (This product is only available in Japan.);SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit
- CBNumber:
- CB2141123
- Molecular Formula:
- C23H27N5
- Molecular Weight:
- 373.49
- MDL Number:
- MFCD01827306
- MOL File:
- 304909-07-7.mol
- MSDS File:
- SDS
| Melting point | 104-106°C |
|---|---|
| Boiling point | 547.4±50.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO with warming |
| form | White solid |
| pka | 7.35±0.10(Predicted) |
| color | White to off-white |
| Sensitive | Moisture & Light Sensitive |
| CAS DataBase Reference | 304909-07-7 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SANT-1 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4572 | SANT-1 ≥98% (HPLC), powder | 304909-07-7 | 5mg | $190 | 2024-03-01 | Buy |
| Sigma-Aldrich | 559303 | SANT-1 | 304909-07-7 | 5mg | $201 | 2024-03-01 | Buy |
| Alfa Aesar | J65294 | SANT-1 | 304909-07-7 | 10mg | $169 | 2023-06-20 | Buy |
| Cayman Chemical | 14933 | SANT 1 ≥98% | 304909-07-7 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14933 | SANT 1 ≥98% | 304909-07-7 | 5mg | $107 | 2024-03-01 | Buy |
SANT-1 Chemical Properties,Uses,Production
Description
Smoothened (SMO) is a GPCR-
Chemical Properties
Pale Yellow Solid
Uses
Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.
Uses
A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).
Definition
ChEBI: 1-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-N-[4-(phenylmethyl)-1-piperazinyl]methanimine is a ring assembly and a member of pyrazoles.
Biological Activity
Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells).
Biochem/physiol Actions
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
storage
Desiccate at +4°C
References
[1]. chen j k., taipale j, young k e,. small molecule modulation of smoothened activity. proc natl acad sci u s a, 2002, 99: 14071-6.
[2]. chun sg, zhou w & yee n s. combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. cancer biol ther, 2009, 8: 1328-39.
SANT-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
