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SANT-1

SANT-1 structure

CAS No.: 304909-07-7

Chemical Name:: SANT-1

Synonyms: SANT-1;CS-1685;SANT1 10MG;SANT1;SANT 1;SANT-1 USP/EP/BP;SANT-1; SANT1;SANT 1;SANT-1 - CAS 304909-07-7 - Calbiochem;SANT-1 (This product is only available in Japan.);SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit;(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine

CBNumber:: CB2141123

Molecular Formula:: C23H27N5

Molecular Weight:: 373.49

MDL Number:: MFCD01827306

MOL File:: 304909-07-7.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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SANT-1 Properties

Melting point	104-106°C
Boiling point	547.4±50.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO with warming
form	White solid
pka	7.35±0.10(Predicted)
Sensitive	Moisture & Light Sensitive
CAS DataBase Reference	304909-07-7

SAFETY

Risk and Safety Statements

WGK Germany	3

SANT-1 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S4572	SANT-1 ≥98% (HPLC), powder	304909-07-7	5mg	$190	2024-03-01	Buy
Sigma-Aldrich	559303	SANT-1	304909-07-7	5mg	$201	2024-03-01	Buy
Alfa Aesar	J65294	SANT-1	304909-07-7	10mg	$169	2023-06-20	Buy
Cayman Chemical	14933	SANT 1 ≥98%	304909-07-7	1mg	$62	2024-03-01	Buy
Cayman Chemical	14933	SANT 1 ≥98%	304909-07-7	5mg	$107	2024-03-01	Buy

Product number	Packaging	Price	Buy
S4572	5mg	$190	Buy
559303	5mg	$201	Buy
J65294	10mg	$169	Buy
14933	1mg	$62	Buy
14933	5mg	$107	Buy

SANT-1 Chemical Properties,Uses,Production

Description

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC₅₀ = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.

Chemical Properties

Pale Yellow Solid

Uses

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells² and chronic lymphocytic leukemia cells³ with SANT-1 induced cell death.

Uses

A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).

Definition

ChEBI: 1-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-N-[4-(phenylmethyl)-1-piperazinyl]methanimine is a ring assembly and a member of pyrazoles.

Biological Activity

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells).

Biochem/physiol Actions

SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.

storage

Desiccate at +4°C

References

[1]. chen j k., taipale j, young k e,. small molecule modulation of smoothened activity. proc natl acad sci u s a, 2002, 99: 14071-6.
[2]. chun sg, zhou w & yee n s. combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. cancer biol ther, 2009, 8: 1328-39.

SANT-1 Preparation Products And Raw materials

Raw materials

Preparation Products

SANT-1 Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	26823	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76

SANT-1 Spectrum

SANT-1(304909-07-7)¹HNMR

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N-[(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHYLENE]-4-(PHENYLMETHYL)-1-PIPERAZINAMINE SANT-1 (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine 1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)- (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine SANT1 10MG SANT1;SANT 1 SANT-1 - CAS 304909-07-7 - Calbiochem CS-1685 SANT-1; SANT1;SANT 1 SANT-1 (This product is only available in Japan.) N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine SANT-1 USP/EP/BP SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit 304909-07-7 C23H27N5 Lipid signaling Inhibitors All Inhibitors API