Uridine-5'-diphosphate disodium salt
- CAS No.
- 27821-45-0
- Chemical Name:
- Uridine-5'-diphosphate disodium salt
- Synonyms
- UDP 2NA;UDP.Na2;5′-UDP,2Na;5'-UDP-Na2;Einecs 248-678-9;5'-UDP 2Na Hydrate;Diquafosol Impurity 17;Uridine 5’-diphosphate;Sodium 1-((2R,3R,4S,5R);Disodiumuridinediphosphate
- CBNumber:
- CB2143213
- Molecular Formula:
- C9H15N2NaO12P2
- Molecular Weight:
- 428.16
- MDL Number:
- MFCD00084679
- MOL File:
- 27821-45-0.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| form | Powder |
| color | White to Off-white |
| biological source | synthetic |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 8817400 |
| InChIKey | KWDGQJWFEYTPBN-IBOJMDDDSA-L |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r| |
| CAS DataBase Reference | 27821-45-0(CAS DataBase Reference) |
| FDA UNII | CU84BH96WL |
| UNSPSC Code | 41106305 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 10-21 |
| HS Code | 29349990 |
Uridine-5'-diphosphate disodium salt price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 94330 | Uridine 5′-diphosphate disodium salt hydrate ≥96.0% (HPLC) | 27821-45-0 | 100mg | $126 | 2024-03-01 | Buy |
| Sigma-Aldrich | 94330 | Uridine 5′-diphosphate disodium salt hydrate ≥96.0% (HPLC) | 27821-45-0 | 500mg | $509 | 2024-03-01 | Buy |
| Alfa Aesar | J64329 | Uridine-5'-diphosphate disodium salt 98% | 27821-45-0 | 100mg | $71.65 | 2024-03-01 | Buy |
| Alfa Aesar | J64329 | Uridine-5'-diphosphate disodium salt 98% | 27821-45-0 | 1g | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 18137 | UDP (sodium salt) ≥95% | 27821-45-0 | 100mg | $32 | 2024-03-01 | Buy |
Uridine-5'-diphosphate disodium salt Chemical Properties,Uses,Production
Description
Uridine-5'-diphosphate disodium salt (UDP-Na2) is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). It is an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. It has also been used as a purinergic agonist, in order to study its effect on the flux of absorbed cations in cochlear outer sulcus cells (OSC) and vestibular migratory cells (VTC). UDP-Na2 has also been used to determine the activity of nucleoside diphosphatase (NDPase) in the rabbit retina.
Uses
Uridine-5'-diphosphate disodium salt is mainly used in nucleic acid (RNA) biosynthesis and cell signalling studies. Uridine-5'-monophosphate disodium salt (UDP-MS) is a structural analogue of uridine and is used as a dietary supplement. It has been shown to inhibit phosphodiesterase and cyclic nucleotide phosphodiesterase, both of which are enzymes that degrade the secondary messenger cyclic adenosine monophosphate (cAMP).
Uses
Uridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).
Application
Uridine 5′-diphosphate disodium salt hydrate has been used:
as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina
Biochem/physiol Actions
Uridine 5′-diphosphate (UDP) is an endogenous signaling molecule produced by damaged cells to attract macrophages. In response to neuronal damage, UDP promotes chemotaxis and chemokinesis in microglial cells. UDP serves as a ligand for P2Y receptors. UDP and uridine 5′-triphosphate (UTP) may be used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled protein receptors (GPCR) and cell signaling molecules such as Rho-signaling via guanine nucleotide exchange factors (GEF).
storage
Store at -20°C
Purification Methods
Crystallise it from MeOH. It may contain some Ba salt(s); hence stir it with Amberlite IR-120 cation exchanger (25mL, wet resin, 15-50 mesh in H+ form) in H2O (50mL) until the nucleotide dissolves. Filter, wash resin with H2O until the eluate is neutral. Combine the filtrate and washings, and adjust the pH to 8.0 with 2.0 M aqueous NaOH. Concentrate it in vacuo to a small volume (~ 20mL), and add Me2CO dropwise until crystallisation begins. Cool to 0o, and the shiny plates of di Na uridine-5’-phosphate dihydrate are filtered off and dried over P2O5 at 25o/0.1mm for 24hours (>76% recovery). UV: max at 262nm ( 10,000 M-1cm -1) in 0.1 M HCl. [Boon et al. J Chem Soc 408 1950, Smith Biochemical Preparations 8 130 1960.] [Beilstein 24 IV 1214.]
Uridine-5'-diphosphate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Hangzhou Weitai Biological Pharmaceutical Co.,Ltd. | +8613282012786 | sales@weitai-pharmaceutical.com | China | 61 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10983 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3922 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3883 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +8618001850931 | sales@meiyapharm.com | China | 58 | 58 |
View Lastest Price from Uridine-5'-diphosphate disodium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-26 | Uridine-5'-diphosphoglucose disodium salt
27821-45-0
|
US $12.00 / KG | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2025-04-25 | Uridine 5’-diphosphate disodium salt,UDP-Na2; UDP; 5'-UDP-Na2
27821-45-0
|
US $0.00-0.00 / kg | 1kg | 98.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. | |
 |
2025-04-25 | Uridine-5'-diphosphoglucose disodium salt
27821-45-0
|
US $0.00 / g | 1g | 98% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Uridine-5'-diphosphoglucose disodium salt
27821-45-0
- US $12.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Uridine 5’-diphosphate disodium salt,UDP-Na2; UDP; 5'-UDP-Na2
27821-45-0
- US $0.00-0.00 / kg
- 98.0%min. HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
-
- Uridine-5'-diphosphoglucose disodium salt
27821-45-0
- US $0.00 / g
- 98%
- WUHAN FORTUNA CHEMICAL CO., LTD