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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) structure

CAS No.: 1477-57-2

Chemical Name:: N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Synonyms: SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine

CBNumber:: CB2146249

Molecular Formula:: C12H20Cl4N2O2

Molecular Weight:: 366.11

MDL Number:: MFCD00000841

MOL File:: 1477-57-2.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Properties

Melting point	118-120 °C
Boiling point	530℃
Density	0.726
refractive index	1.6200 (estimate)
Flash point	275℃
storage temp.	Inert atmosphere,2-8°C
solubility	Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
pka	12.28±0.46(Predicted)
form	Solid
color	White to Off-White
CAS DataBase Reference	1477-57-2
FDA UNII	3F56RA64JN

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H312+H332-H351

Precautionary statements

P202-P261-P280-P302+P352+P312-P304+P340+P312-P308+P313

Hazard Codes

Risk Statements

20/21/22-40

Safety Statements

24/25-45-36

Toxicity

LD50 orally in mice: >16000 mg/kg (Coulston)

NFPA 704

	1
2		0

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3187	WIN 18446 ≥98% (HPLC)	1477-57-2	50MG	$123	2024-03-01	Buy
Cayman Chemical	14018	WIN 18,446 ≥98%	1477-57-2	50mg	$62	2024-03-01	Buy
Cayman Chemical	14018	WIN 18,446 ≥98%	1477-57-2	100mg	$109	2024-03-01	Buy
Cayman Chemical	14018	WIN 18,446 ≥98%	1477-57-2	250mg	$151	2024-03-01	Buy
Tocris	4736	WIN18446	1477-57-2	50	$125	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML3187	50MG	$123	Buy
14018	50mg	$62	Buy
14018	100mg	$109	Buy
14018	250mg	$151	Buy
4736	50	$125	Buy

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

Win 18446 was shown to inhibit the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis and in the embryonic murine gonad.

Definition

ChEBI: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neon tal and adult murine testis. It down-regulates sex related genes in zebrafish.

Biological Activity

win 18446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2 (aldh1a2), with ic50 value of 300 nm [1].aldh1a2, expressed almost exclusively in the testes, localizes to developing germ cells within the seminiferous tubules and strongly binds retinol, but does not recognize acetaldehyde as a substrate, suggesting that aldh1a2 functions in testicular retinoic acid biosynthesis [1].in whole testes or germ cells isolated from mice at 2 days postpartum, win 18,446 alone (1 μm) or in combination with retinol significantly reduced the expression of stra8, a marker for retinoic acid activity [2].in male rabbits, oral administration of win 18446 at 200 mg/kg for 16 weeks substantially reduced intratesticular concentrations of retinoic acid, significantly impaired spermatogenesis, and resulted in infertility. reduced concentrations of intratesticular retinoic acid became obvious after only 4 weeks of treatment and preceded the decrease in sperm counts and the loss of mature germ cells in tissue samples. sperm counts and fertility recovered after treatment was discontinued [1].[1]. amory j k, muller c h, shimshoni j a, et al. suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. journal of andrology, 2011, 32(1): 111-119.[2]. hogarth c a, evanoff r, snyder e, et al. suppression of stra8 expression in the mouse gonad by win 18,446. biology of reproduction, 2011, 84(5): 957-965.

Safety Profile

Poison by intraperitoneal route.Human systemic effects by ingestion: nausea andvomiting. Human reproductive effects by ingestion:changes in spermatogenesis. An experimental teratogen.Other experimental reproductive effects. Human mutationdata reporte

storage

Store at +4°C

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3741	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Finetech Industry Limited	58
CD Chemical Group Limited	58
LEAP CHEM CO., LTD.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	WIN 18446 1477-57-2	US $34.00-73.00 / mg		99.69%	10g	TargetMol Chemicals Inc.
	2024-07-26	N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 1477-57-2	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd

WIN 18446
1477-57-2
US $34.00-73.00 / mg
99.69%
TargetMol Chemicals Inc.

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
1477-57-2
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Spectrum

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)(1477-57-2)¹HNMR N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)(1477-57-2)IR1 N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)(1477-57-2)IR2

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FERTILYSIN N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE] N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) bisdiamine bis-diamine n,n’,1,8-octanediylbis(2,2-dichloro-acetamid n,n’-bis(dichloroacetyl)-1,8-diaminooctane n,n’-bis(dichloroacetyl)-1,8-octanediamine n,n’-octamethylenebis(2,2-dichloro-acetamid n,n’-octamethylenebis(2,2-dichloroactamide) n,n-bis(dichloroacetyl)-1,8-octanediamine r-010-tk win18,446 win18441 win18446 NSC 59354 N,N''-OCTMETHYLENEBIS (DICHLOROACETAMIDE) N,N'-(1,8-Octanediyl)bis(2,2-dichloroacetamide) N,N'-Octamethylenebis(dichloroacetamide),97% N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetaMide) AcetaMide,N,N'-1,8-octanediylbis[2,2-dichloro- Fertilysine SKL878 WIN 18446,Stra8,testis,spermatogenesis,inhibit,Win18446,Aldehyde Dehydrogenase (ALDH),Testes,Win-18446,Inhibitor 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide) N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) ACETAMIDE,N,N'-1,8-OCTANEDIYLBIS[2,2-DICHLORO- 1477-57-2 C12H20Cl4N2O2