Cefapirin sodium

Cefapirin sodium Properties

Melting point	>177°C (dec.)
alpha	+152～+170゜(25℃/D)(c=2,H2O)(calculated on the dehydrous basis)
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in water, practically insoluble in methylene chloride.
form	powder
pka	pKa 2.15 (Uncertain)
color	Light Beige to Beige
InChIKey	VGEOUKPOQQEQSX-OALZAMAHSA-M
CAS DataBase Reference	24356-60-3(CAS DataBase Reference)
FDA 21 CFR	556.115
FDA UNII	431LFF7I7J

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H317-H319-H334-H335
Precautionary statements	P261-P280-P284-P304+P340-P305+P351+P338-P342+P311
Hazard Codes	Xn
Risk Statements	36/37/38-42/43
Safety Statements	26-36
RTECS	XI0382000
HS Code	2941906000

Cefapirin sodium price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000240	Cefapirin sodium European Pharmacopoeia (EP) Reference Standard	24356-60-3	y0000240	$220	2024-03-01	Buy
Sigma-Aldrich	SMB00605	Cephapirin sodium ≥96%	24356-60-3	25mg	$321	2023-06-20	Buy
Sigma-Aldrich	1102500	Cephapirin sodium United States Pharmacopeia (USP) Reference Standard	24356-60-3	500mg	$436	2024-03-01	Buy
TRC	C261510	Cephapirin sodium	24356-60-3	10mg	$140	2021-12-16	Buy
ChemScene	CS-0031236	Cephapirin sodium 99.59%	24356-60-3	100mg	$135	2021-12-16	Buy

Product number	Packaging	Price	Buy
Y0000240	y0000240	$220	Buy
SMB00605	25mg	$321	Buy
1102500	500mg	$436	Buy
C261510	10mg	$140	Buy
CS-0031236	100mg	$135	Buy

Cefapirin sodium Chemical Properties,Uses,Production

Description

Cephapirin sodium (Cefapirin sodium), a semisynthetic cephalosporin antibiotic, is bactericidal against strains of gram-positive and gram-negative bacteria.
Cephapirin is closely resembles cephalothin in chemical and pharmacokinetic properties. Cephapirin, have cephalosporanic acid core with the acetyloxymethyl group at the 3rd position and having IUPAC name (6R,7R)-3-(Acetoxymethy)-8- oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia- 1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid. It is unstable in acid and must be administered parenteral. It has similar mechanism as other cephalosporins. It is marketed under the trade name Cefadyl. It is effective against a wide variety of gram-positive and gramnegative bacteria; used as the sodium salt. Among the most serious adverse reactions of cefapirin, that is， neutropenia, leukopenia, anemia, bone marrowdepression, and allergic reactions, it has been discontinued in the United States (Wiesner, 1972).

Chemical Properties

White or pale yellow powder.

Originator

Cefadyl,Bristol,US,1974

Uses

Cefapirin sodium is very similar to cephalothin (Bran et al., 1972). Cephapirin is now used almost exclusively in veterinary practice.

Application

Cephapirin was synthesized by BristolMyers Laboratories in 1970. It shows almost the same in vitro antibacterial activity as cephalothin, but its in vivo effects are slightly greater than those of cephalothin. Like cephalothin, it is metabolized in vivo, and its deacetylated metabolite shows almost the same activity against gram-positive bacteria as cephalothin, but weaker activity against gramnegative bacteria. Cephapirin has been used for therapy of urinary tract infections and osteomyelitis caused by Staphylococcus, Streptococcus, and Escherichia coli.

Definition

ChEBI: Cephapirin sodium is the sodium salt of cephapirin. A first-generation cephalosporin antibiotic, it is effective against gram-negative and gram-positive organisms. Being more resistant to beta-lactamases than penicillins, it is effective agains most staphylococci, though not methicillin-resistant staphylococci. It has a role as an antibacterial drug. It is a cephalosporin and an organic sodium salt. It contains a cephapirin(1-).

brand name

Cefadyl (Apothecon), ToDAY

Therapeutic Function

Antibacterial

Synthesis

Cephapirin, (6R-trans)-3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio) acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.4), is synthesized by acylating 7-aminocephalosporanic acid with 4-pyridylthioacetic acid chloride (32.1.2.3), which is synthesized by reacting 4-chloropyridine with mercaptoacetic acid in the presence of a base, forming 4-pyridylthioacetic acid (32.1.22), and further transforming the resulting acid to the acid chloride by reacting it with phosphorous pentachloride.
An alternative way of making cephapirin is the acylation of 7-aminocephalosporanic acid by bromoacetyl bromide, which gives a bromoacetyl derivative (32.1.2.5), and which is then reacted with 4-mercaptopyridine in the presence of triethylamine, forming the desired cephapirin (32.1.2.4). Synthesis_24356-60-3

Cefapirin sodium Preparation Products And Raw materials

Raw materials

Aminocephalosporanic acid Bromoacetyl bromide Sodium bicarbonate 2-Mercaptopyrimidine Sodium 2-ethylhexanoate

Preparation Products

Cefapirin sodium Suppliers

Global( 174)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18779	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58

Supplier	Advantage
Finetech Industry Limited	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Qiuxian Baitai New Material Co., LTD	58

View Lastest Price from Cefapirin sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Cephapirin Sodium 24356-60-3	US $30.00-52.00 / mg		95.54%	10g	TargetMol Chemicals Inc.
2021-11-23	Cefapirin sodium 24356-60-3	US $10.00 / g	100g	99.99%	5ton/Month	Qiuxian Baitai New Material Co., LTD
2020-05-26	Cefapirin sodium 24356-60-3	US $0.00-0.00 / Kg	1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd

Cephapirin Sodium
24356-60-3
US $30.00-52.00 / mg
95.54%
TargetMol Chemicals Inc.

Cefapirin sodium
24356-60-3
US $10.00 / g
99.99%
Qiuxian Baitai New Material Co., LTD

Cefapirin sodium
24356-60-3
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

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cephapirin sodium crystalline sodium (6R-trans)-3-(acetoxymethyl)-8-oxo-7-[(4-pyridylthio)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate CEPHAPIRIN BEUZATHINE 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 3-(acetyloxy)methyl-8-oxo-7-(4-pyridinylthio)acetylamino-, monosodium salt, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester), monosodium salt (8CI) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodium salt, (6R-trans)- 7-[α-(4-Pyridylthio)acetamido]cephalosporanic acid sodium salt Ambrocef Brisfirina Bristocef Cefa-Lak Cef-Lak NSC 179171 Piricef 2,0)oct-2-ene-2-carboxylicacid,3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo( 7-(2-(4-pyridylthio)acetamido)-,acetate(ester),monosodiumsalt blp1322 CEPHAPIRIN SODIUM SALT Sodium (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cephapirin sodium, 3-[(Acetyloxy)methyl]-8-oxo-7-{(4-pyridinylthio)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt Cefapirine Sodium Cephapirin Sodium (500 mg) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)Methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]aMino]-, sodiuMsalt (1:1) cefaloject cefapirinsodium cefaprinsodium cefatrexyl cephatrexil cephatrexyl sodiumcefapirin sodiumcephapirin Cephapirin Sodium (1102500) Sodium (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(2-(pyridin-4-ylthio)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cefapirin sodium USP/EP/BP CEFAPIRIN USP/EP/BP Cefapirin sodiu Cefapirin sodium CRS 3-[(Acetyloxy)methyl]-8-oxo-7-{(4-pyridinylthio)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt Cefapirin Sodium Salt Today CEFADYL CEPHAPIRIN CEPHAPIRIN SODIUM C11064071 Cefapirin sodium 24356-60-3 94768-37-6 C17H17N3O6S2 C17H16N3NaO6S2 C17H16N3O6S2Na C17H17N3NaO6S2 CEFADYL