Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
- CAS No.
- 73029-73-9
- Chemical Name:
- Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
- Synonyms
- CyPPA;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl);KcsA,inhibit,CyPPA,Potassium Channel,Inhibitor;N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine;N-cyclohexyl-6-methyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine;N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine;Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine;N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine;4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-
- CBNumber:
- CB22094094
- Molecular Formula:
- C16H23N5
- Molecular Weight:
- 285.39
- MDL Number:
- MFCD01550586
- MOL File:
- 73029-73-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335-H413 | |||||||||
Precautionary statements | P273-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C5493 | CyPPA ≥98% (HPLC), solid | 73029-73-9 | 5mg | $149 | 2024-03-01 | Buy |
Sigma-Aldrich | C5493 | CyPPA ≥98% (HPLC), solid | 73029-73-9 | 25mg | $660 | 2024-03-01 | Buy |
Cayman Chemical | 15614 | CyPPA ≥98% | 73029-73-9 | 10mg | $127 | 2024-03-01 | Buy |
Cayman Chemical | 15614 | CyPPA ≥98% | 73029-73-9 | 50mg | $601 | 2024-03-01 | Buy |
Tocris | 2953 | CyPPA ≥99%(HPLC) | 73029-73-9 | 25 | $389 | 2021-12-16 | Buy |
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Chemical Properties,Uses,Production
Uses
CyPPA is a positive SK3/SK2 modulator that reduces the activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methyl phenidate.
Uses
CyPPA has been used:
- to test its inhibitory functionality on melanogenesis
- as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
- in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells
Biological Activity
Activator of small conductance Ca 2+ -activated K + channels that displays selectivity for SK2 and SK3 channels (EC 50 values are 5.6 and 14 μ M for SK3 and SK2 respectively). Displays no activity at SK1 and IK channels.
Biochem/physiol Actions
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.
storage
+4°C
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |