(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one
- CAS No.
- 6157-00-2
- Chemical Name:
- (3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one
- Synonyms
- Pachystermine B;(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one;2-Azetidinone, 1-[(3β,4β,5α,20S)-20-(dimethylamino)-4-hydroxypregnan-3-yl]-3-(1-methylethyl)-, (3R)-
- CBNumber:
- CB22263632
- Molecular Formula:
- C29H50N2O2
- Molecular Weight:
- 458.72
- MDL Number:
- MOL File:
- 6157-00-2.mol
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Chemical Properties,Uses,Production
Description
This alkaloid, in which the pregnane keto group of the preceding base is reduced to a secondary hydroxyl group, occurs in small amounts in Pachysandra termi_x0002_nalis Sieb. et Zucco It is laevorotatory having [O:]D - 18° (CHC13). Oxidation with chromic acid yields Pachystermine A.
References
Kikuchi, Uyeo., Tetrahedron Lett., 3473 (1965)
Kikuchi, Uyeo., Chern. Pharrn. Bull., 15, 549 (1967)
Partial synthesis:
Kikuchi et aZ., Tetrahedron Lett., 909 (1968)
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
Pachystermine B
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one
2-Azetidinone, 1-[(3β,4β,5α,20S)-20-(dimethylamino)-4-hydroxypregnan-3-yl]-3-(1-methylethyl)-, (3R)-
6157-00-2