ACOLBIFENE
- CAS No.
- 151533-34-5
- Chemical Name:
- ACOLBIFENE
- Synonyms
- ACOLBIFENE;(Rac)-EM-652;rac-Acolbifene;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-;2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
- CBNumber:
- CB22451259
- Molecular Formula:
- C29H31NO4
- Molecular Weight:
- 457.56
- MDL Number:
- MFCD09837712
- MOL File:
- 151533-34-5.mol
| Boiling point | 651.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.217±0.06 g/cm3(Predicted) |
| solubility | DMSO: 100 mg/mL (218.55 mM) |
| pka | 9.70±0.40(Predicted) |
| form | Crystal |
| color | Purple to purplish red |
| FDA UNII | 815LJ9X0D1 |
ACOLBIFENE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A190235 | rac-Acolbifene | 151533-34-5 | 10mg | $165 | 2021-12-16 | Buy |
| TRC | A190235 | rac-Acolbifene | 151533-34-5 | 100mg | $1320 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0019241 | ACOLBIFENE 95.00% | 151533-34-5 | 5MG | $501.22 | 2021-12-16 | Buy |
ACOLBIFENE Chemical Properties,Uses,Production
Description
The prodrug EM-800 is an orally active nonsteroidal anties trogen and is a triphenylethylene rigid analogue. EM-800 undergoes ester hydrolysis to the active m etabolite acolbifene. This fourth-generation antiestrogen is 200-fold more potent than tam oxifen in breast and uterine cancer cells and is effective in patients for whom tamoxifen therapy has failed. The mechanistic rationale for the effectiveness of acolbifene in tamoxifen-resistant tumors is based on the fact that it inhibits both the AF-1 and AF-2 activation pathways and does not poss ess any intrinsic estrogenic action. Acolbifene enjoys a 60% breast cancer cure rate. Structurally, acolbifene resembles raloxifene, with a benzopyran ring substituted for the benz othiophene ring. An additional benefit observed with acolbifene is its protective effect on bone loss. Adverse effects include nausea and vomiting.
Uses
rac-Acolbifene is a reacemic compound of Acolbifene (A190230) which is a selective estrogen receptor modulator (SERM) acting as pure antiestrogen. Acolbifene is also the orally active antiestrogen which is the most potent of the known antiestrogens and exerts pure antiestrogenic activity in the mammary gland and endometrium.
ACOLBIFENE Preparation Products And Raw materials
Raw materials
Preparation Products
ACOLBIFENE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56057 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |