아콜비펜
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아콜비펜 속성
- 끓는 점
- 651.5±55.0 °C(Predicted)
- 밀도
- 1.217±0.06 g/cm3(Predicted)
- 용해도
- DMSO: 100 mg/mL (218.55 mM)
- 산도 계수 (pKa)
- 9.70±0.40(Predicted)
- 물리적 상태
- Crystal
- 색상
- Purple to purplish red
안전
아콜비펜 C화학적 특성, 용도, 생산
개요
The prodrug EM-800 is an orally active nonsteroidal anties trogen and is a triphenylethylene rigid analogue. EM-800 undergoes ester hydrolysis to the active m etabolite acolbifene. This fourth-generation antiestrogen is 200-fold more potent than tam oxifen in breast and uterine cancer cells and is effective in patients for whom tamoxifen therapy has failed. The mechanistic rationale for the effectiveness of acolbifene in tamoxifen-resistant tumors is based on the fact that it inhibits both the AF-1 and AF-2 activation pathways and does not poss ess any intrinsic estrogenic action. Acolbifene enjoys a 60% breast cancer cure rate. Structurally, acolbifene resembles raloxifene, with a benzopyran ring substituted for the benz othiophene ring. An additional benefit observed with acolbifene is its protective effect on bone loss. Adverse effects include nausea and vomiting.아콜비펜 준비 용품 및 원자재
원자재
준비 용품
아콜비펜 공급 업체
글로벌( 22)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
China | 1494 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 |
sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | |
eric_feng1954@126.com | China | 9254 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 |
sales@rrkchem.com | China | 56068 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44843 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; |
psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24017 | 58 |