Terameprocol
- CAS No.
- 24150-24-1
- Chemical Name:
- Terameprocol
- Synonyms
- M4N;TMNDGA;EM-1421;Terameprocol;TETRAMEPROCOL;TETRAMETHYL NDGA;tetra-O-methyl-NDGA;TETRAMETHYL NORDIHYDROGUAIARETIC ACID;Tetra-O-methyl nordihydroguaiaretic acid;Meso-tetra-o-methylnordihydroguaiaretic acid
- CBNumber:
- CB22456380
- Molecular Formula:
- C22H30O4
- Molecular Weight:
- 358.47
- MDL Number:
- MFCD11113155
- MOL File:
- 24150-24-1.mol
| Melting point | 101-102 °C |
|---|---|
| Boiling point | 458.5±40.0 °C(Predicted) |
| Density | 1.036±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to off-white |
| NCI Dictionary of Cancer Terms | EM-1421; tetra-O-methyl NDGA; tetra-O-methyl nordihydroguaiaretic acid |
| FDA UNII | 53YET703F2 |
Terameprocol price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T3455 | Terameprocol ≥98% (HPLC) | 24150-24-1 | 10mg | $90 | 2024-03-01 | Buy |
| Sigma-Aldrich | T3455 | Terameprocol ≥98% (HPLC) | 24150-24-1 | 50mg | $354 | 2024-03-01 | Buy |
| Cayman Chemical | 70302 | tetramethyl Nordihydroguaiaretic Acid ≥95% | 24150-24-1 | 50mg | $16 | 2024-03-01 | Buy |
| Cayman Chemical | 70302 | tetramethyl Nordihydroguaiaretic Acid ≥95% | 24150-24-1 | 1g | $188 | 2024-03-01 | Buy |
| Cayman Chemical | 70302 | tetramethyl Nordihydroguaiaretic Acid ≥95% | 24150-24-1 | 100mg | $28 | 2024-03-01 | Buy |
Terameprocol Chemical Properties,Uses,Production
Uses
Terameprocol is a synthetic derivative of NDGA and non-selective lipoxygenase inhibitor.
Definition
ChEBI: Terameprocol is a lignan.
Biological Activity
tetramethyl nordihydroguaiaretic acid (tmndga) is a synthetic derivative of ndga (nordihydroguaiaretic acid), a non-selective lipoxygenase inhibitor. tmndga showed the strongest anti-hiv activity.
in vitro
in vero cells, tmndga inhibited sp1 transcription factor binding at the hiv long terminal repeat promoter and at the α-icp4 promoter with ic50 values of 11 and 43.5 μm, respectively. the ic50 of tmndga varied between 11.7 and 4 μm in 10 passages of hsv-1 and 4 passages of hsv-2 [2]. tmndga inhibited sp1-dependent cdc2 gene expression. in m4n-treated transformed c3 cells, tmndga induced growth arrest and apoptosis by suppressing sp1-dependent cdc2 and survivin gene expression giving rise to its antitumorigenic activity [3]. tmndga treatment suppressed expression of the sp1-dependent survivin gene. in transiently and stably survivin-transfected c3 cells, tmndga reduced caspase-3 activation by 50% and 75%, respectively [3]. tmndga inhibited the growth of a number of tumor cell lines by inducing apoptosis in a non-schedule-dependent manner [4]. tmndga inhibited the synthesis of dna by melanoma cells and causes cell cycle arrest in g0/g1 and g2/m phases of the cell cycle [4].
in vivo
tmndga effectively inhibited the growth of human tumors in nude mice [5]. tmndga inhibited the growth of both murine and human melanomas and human colon cancer without apparent hepatic or renal toxicity [4]. in nude (nu/nu) mice bearing xenografts of human tumor types (hep 3b, lncap, ht-29, mcf7, and k-562), treatment with tmndga (i.v. or i.p.) down-regulated cdc2 and survivin genes expression [5].
References
[1] hwu j r, tseng w n, gnabre j, et al. antiviral activities of methylated nordihydroguaiaretic acids. 1. synthesis, structure identification, and inhibition of tat-regulated hiv transactivation[j]. journal of medicinal chemistry, 1998, 41(16): 2994-3000.
[2] chen h, teng l, li j n, et al. antiviral activities of methylated nordihydroguaiaretic acids. 2. targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-o-methyl-ndga[j]. journal of medicinal chemistry, 1998, 41(16): 3001-3007.
[3] chang c c, heller j d, kuo j, et al. tetra-o-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting cdc2 and survivin expression[j]. proceedings of the national academy of sciences of the united states of america, 2004, 101(36): 13239-13244.
[4] lambert j d, meyers r o, timmermann b n, et al. tetra-o-methylnordihydroguaiaretic acid inhibits melanoma in vivo[j]. cancer letters, 2001, 171(1): 47-56.
[5] park r, chang c c, liang y c, et al. systemic treatment with tetra-o-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors[j]. clinical cancer research, 2005, 11(12): 4601-4609.
Terameprocol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1493 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Henan Kehong Biological Technology Co. LTD | 0371-55969461； 0371-86658258 17722895060 | info@kehobio.com | China | 2408 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18478 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
View Lastest Price from Terameprocol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Terameprocol
24150-24-1
|
US $45.00-132.00 / mg | 99.38% | 10g | TargetMol Chemicals Inc. |
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- Terameprocol
24150-24-1
- US $45.00-132.00 / mg
- 99.38%
- TargetMol Chemicals Inc.