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ChemicalBook >> CAS DataBase List >>3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Structure
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide structure
CAS No.
765317-72-4
Chemical Name:
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
Synonyms
6-BenzofuransulfonaMide, 3-(3,5-dibroMo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylaMino)sulfonyl]phenyl]-;3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide;PTP1B-IN-4;PTP1B Inhibitor inhibitor;3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
CBNumber:
CB22499424
Molecular Formula:
C26H19Br2N3O7S3
Molecular Weight:
741.45
MDL Number:
MFCD09037556
MOL File:
765317-72-4.mol
Last updated:2024-07-02 08:55:03
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3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Properties

Boiling point 855.0±75.0 °C(Predicted)
Density 1.812±0.06 g/cm3(Predicted)
storage temp. Store at -20°C, protect from light
solubility Soluble in ethanol and DMSO
pka 4.47±0.25(Predicted)
form Solid
color White to off-white
Sensitive Light Sensitive

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 539741 PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC?? = 4 μM and 8 μM for PTP1B403 and PTP1B298, respectively). 765317-72-4 5MG $280 2023-06-20 Buy
Alfa Aesar J64512 PTP1B Inhibitor 765317-72-4 5mg $479 2023-06-20 Buy
Cayman Chemical 15782 PTP1B Inhibitor ≥98% 765317-72-4 500μg $61 2024-03-01 Buy
Cayman Chemical 15782 PTP1B Inhibitor ≥98% 765317-72-4 1mg $112 2024-03-01 Buy
Cayman Chemical 15782 PTP1B Inhibitor ≥98% 765317-72-4 5mg $264 2024-03-01 Buy
Product number Packaging Price Buy
539741 5MG $280 Buy
J64512 5mg $479 Buy
15782 500μg $61 Buy
15782 1mg $112 Buy
15782 5mg $264 Buy

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Chemical Properties,Uses,Production

Description

Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 μM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the conformation of the catalytic pocket. PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.

Uses

PTP1B Inhibitor is used as a PTP1B inhibitor blocks the activity of the Protein Tyrosine Phosphatase 1B, which is a key factor in the negative regulation of insulin and leptin signaling pathway. Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4694 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
China Langchem Inc. 0086-21-58956006 China 7815 57
Supplier Advantage
Alchem Pharmtech,Inc. 		58
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Amadis Chemical Company Limited 		58
VDM Biochemicals 64
China Langchem Inc. 57
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide 6-BenzofuransulfonaMide, 3-(3,5-dibroMo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylaMino)sulfonyl]phenyl]- 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide PTP1B-IN-4 PTP1B Inhibitor inhibitor 765317-72-4 C26H19Br2N3O7S3