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OSU-03012

OSU-03012 Structure
OSU-03012 structure
CAS No.
742112-33-0
Chemical Name:
OSU-03012
Synonyms
AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;N/AAR-12; OSU03012; OSU 03012;OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012;2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
CBNumber:
CB22501006
Molecular Formula:
C26H19F3N4O
Molecular Weight:
460.45
MDL Number:
MFCD12912272
MOL File:
742112-33-0.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:03
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OSU-03012 Properties

storage temp. Store at -20°C
solubility ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form solid
color White to off-white
CAS DataBase Reference 742112-33-0
FDA UNII EX3O2Q61UV

OSU-03012 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10008005 OSU03012 742112-33-0 10mg $116 2024-03-01 Buy
Cayman Chemical 10008005 OSU03012 742112-33-0 100mg $789 2024-03-01 Buy
Cayman Chemical 10008005 OSU03012 742112-33-0 5mg $73 2024-03-01 Buy
Cayman Chemical 10008005 OSU03012 742112-33-0 50mg $502 2024-03-01 Buy
Tocris 5682 OSU03012 ≥98%(HPLC) 742112-33-0 50 $648 2021-12-16 Buy
Product number Packaging Price Buy
10008005 10mg $116 Buy
10008005 100mg $789 Buy
10008005 5mg $73 Buy
10008005 50mg $502 Buy
5682 50 $648 Buy

OSU-03012 Chemical Properties,Uses,Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC50 value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

storage

Store at -20°C

References

[1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
[2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.

OSU-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

OSU-03012 Suppliers

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29798 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29901 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 26317 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from OSU-03012 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
OSU-03012 pictures 2019-07-06 OSU-03012
742112-33-0
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • OSU-03012 pictures
  • OSU-03012
    742112-33-0
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

OSU-03012 Spectrum

OSU-03012(742112-33-0)1HNMR

742112-33-0(OSU-03012)Related Search:

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OSU-03012, >=98% OSU-03012 (AR-12) 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 N/AAR-12 OSU-03012 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012 CS-1848 N/AAR-12; OSU03012; OSU 03012 Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- OSU-03012 USP/EP/BP AR-12 742112-33-0 C26H19F3N4O Inhibitors Inhibitor of phosphoinositide-dependent kinase-1. Akt mTOR PI3K