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CAY10606

CAY10606 Structure
CAY10606 structure
CAS No.
1159576-98-3
Chemical Name:
CAY10606
Synonyms
CAY10606;2-[(3-Chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester;1H-Benz[g]indole-3-carboxylic acid, 2-[(3-chlorophenyl)methyl]-5-hydroxy-, ethyl ester
CBNumber:
CB22590440
Molecular Formula:
C22H18ClNO3
Molecular Weight:
379.84
MDL Number:
MFCD18382112
MOL File:
1159576-98-3.mol
Last updated:2023-05-21 10:59:17
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CAY10606 Properties

Melting point 222 °C(Solv: ethyl acetate (141-78-6); cyclohexane (110-82-7))
Boiling point 624.2±55.0 °C(Predicted)
Density 1.355±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
form A crystalline solid
pka 8.86±0.30(Predicted)

CAY10606 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13381 CAY10606 ≥98% 1159576-98-3 1mg $62 2024-03-01 Buy
Cayman Chemical 13381 CAY10606 ≥98% 1159576-98-3 5mg $270 2024-03-01 Buy
Cayman Chemical 13381 CAY10606 ≥98% 1159576-98-3 10mg $392 2021-12-16 Buy
TRC B405078 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylicacid,ethylester 1159576-98-3 2.5mg $100 2021-12-16 Buy
TRC B405078 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylicacid,ethylester 1159576-98-3 1mg $50 2021-12-16 Buy
Product number Packaging Price Buy
13381 1mg $62 Buy
13381 5mg $270 Buy
13381 10mg $392 Buy
B405078 2.5mg $100 Buy
B405078 1mg $50 Buy

CAY10606 Chemical Properties,Uses,Production

Description

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).1 It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.1

References

1. Karg, E.M., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase J. Med. Chem. 52,3474-3483(2009).

CAY10606 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10606 Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7980 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28091 58
Supplier Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
CAY10606 2-[(3-Chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester 1H-Benz[g]indole-3-carboxylic acid, 2-[(3-chlorophenyl)methyl]-5-hydroxy-, ethyl ester 1159576-98-3