ChemicalBook >> CAS DataBase List >>N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide structure

CAS No.: 1109283-93-3

Chemical Name:: N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide

Synonyms: MARK-IN-1;MARK IN 1,MARKIN1;N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a;N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide;N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide;2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-

CBNumber:: CB22598815

Molecular Formula:: C22H23F2N7OS

Molecular Weight:: 471.53

MDL Number:: MFCD22419376

MOL File:: 1109283-93-3.mol

MSDS File:: SDS

Last updated:2024-07-02 08:55:03

Request For Quotation

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
color	Light yellow to yellow

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	CCH0032703	N-((1R,6R)-6-AMINO-2,2-DIFLUOROCYCLOHEXYL)-5-METHYL-4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)THIOPHENE-2-CARBOXAMIDE 95.00%	1109283-93-3	5MG	$500.69	2021-12-16	Buy
American Custom Chemicals Corporation	CCH0032703	N-((1R,6R)-6-AMINO-2,2-DIFLUOROCYCLOHEXYL)-5-METHYL-4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)THIOPHENE-2-CARBOXAMIDE 95.00%	1109283-93-3	1G	$1282.05	2021-12-16	Buy

Product number	Packaging	Price	Buy
CCH0032703	5MG	$500.69	Buy
CCH0032703	1G	$1282.05	Buy

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Chemical Properties,Uses,Production

Description

MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM.

MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].

References

[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6.

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide 2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]- MARK-IN-1 MARK IN 1,MARKIN1 1109283-93-3 C22H23F2N7OS