ChemicalBook >> CAS DataBase List >>N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide
- CAS No.
- 1109283-93-3
- Chemical Name:
- N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide
- Synonyms
- MARK-IN-1;MARK IN 1,MARKIN1;N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a;N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide;N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide;2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-
- CBNumber:
- CB22598815
- Molecular Formula:
- C22H23F2N7OS
- Molecular Weight:
- 471.53
- MDL Number:
- MFCD22419376
- MOL File:
- 1109283-93-3.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:03
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | CCH0032703 | N-((1R,6R)-6-AMINO-2,2-DIFLUOROCYCLOHEXYL)-5-METHYL-4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)THIOPHENE-2-CARBOXAMIDE 95.00% | 1109283-93-3 | 5MG | $500.69 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CCH0032703 | N-((1R,6R)-6-AMINO-2,2-DIFLUOROCYCLOHEXYL)-5-METHYL-4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)THIOPHENE-2-CARBOXAMIDE 95.00% | 1109283-93-3 | 1G | $1282.05 | 2021-12-16 | Buy |
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Chemical Properties,Uses,Production
Description
MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM.
MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].
References
[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6.
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Suppliers
Global( 4)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
TargetMol Chemicals Inc. | 58 |
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide
N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a
N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide
2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-
MARK-IN-1
MARK IN 1,MARKIN1
1109283-93-3
C22H23F2N7OS