Hexafluoroacetone trihydrate
- CAS No.
- 34202-69-2
- Chemical Name:
- Hexafluoroacetone trihydrate
- Synonyms
- HEXAFLUOROACETONE HYDRATE;gc7787;HFA·3H2O;Hexafluoroacet;uoroacetone trihydrate;Protirelin Impurity 12;Perfluoroacetone hydrate;PERFLUOROACETONE TRIHYDRATE;hexafluoro-acetontrihydrate;Hexafluoracetone trihydrate
- CBNumber:
- CB2264341
- Molecular Formula:
- C3H6F6O4
- Molecular Weight:
- 220.07
- MDL Number:
- MFCD00149061
- MOL File:
- 34202-69-2.mol
- MSDS File:
- SDS
| Melting point | 18-21 °C(lit.) |
|---|---|
| Boiling point | 106-108 °C |
| Density | 1.579 g/mL at 25 °C(lit.) |
| vapor pressure | 87.5 psi ( 21 °C) |
| refractive index |
n |
| Flash point | 105-106°C |
| Water Solubility | Completely soluble in water |
| form | liquid |
| Specific Gravity | 1.579 |
| color | colorless |
| Merck | 14,4685 |
| BRN | 607236 |
| InChI | InChI=1S/C3F6O.3H2O/c4-2(5,6)1(10)3(7,8)9;;;/h;3*1H2 |
| InChIKey | SNZAEUWCEHDROX-UHFFFAOYSA-N |
| SMILES | C(F)(F)(F)C(=O)C(F)(F)F.O.O.O |
| CAS DataBase Reference | 34202-69-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331-H310-H314-H361 | |||||||||
| Precautionary statements | P202-P261-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-34-63 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2552 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UC2700000 | |||||||||
| Hazard Note | Highly Toxic | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2914790090 | |||||||||
| NFPA 704 |
|
Hexafluoroacetone trihydrate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 139238 | Hexafluoroacetone trihydrate 98% | 34202-69-2 | 5g | $26.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 139238 | Hexafluoroacetone trihydrate 98% | 34202-69-2 | 25g | $102 | 2024-03-01 | Buy |
| TCI Chemical | H0425 | Hexafluoroacetone Hydrate >97.0%(T) | 34202-69-2 | 5g | $23 | 2023-06-20 | Buy |
| TCI Chemical | H0425 | Hexafluoroacetone Hydrate >97.0%(T) | 34202-69-2 | 25g | $46 | 2023-06-20 | Buy |
| Alfa Aesar | L10777 | Hexafluoroacetone trihydrate, 98% | 34202-69-2 | 5g | $31.65 | 2024-03-01 | Buy |
Hexafluoroacetone trihydrate Chemical Properties,Uses,Production
Description
Hexafluoroacetone trihydrate, also known as gem diol, hexafluoropropan-2,2- diol, is a covalent hydrate of the ketone. It could used as a structure stabilizer for peptides. It was a metabolite of aerosol propellant HFA-227 and is present in the urine. It was shown to undergo an efficient carbonyl-ene reaction with a variety of alkenes in the presence of molecular sieves under microwave heating and conventional heating producing hexafluoroisopropanol functionalized derivatives in high yields[1-2].
Uses
Hexafluoroacetone trihydrate (HFA?3H2O) is used to produce Sevoflurane,a high quality anesthetic and Bisphenol AF, a crosslinker for fluoroelastomers. It can also be used to produce various high-end fluorinated products such as fluorinated polyimide, etc.
Uses
Hexafluoroacetone trihydrate was used to study the kinetics and thermodynamics of linkage isomerization of (acetone)pentaammineruthenium (III) and-ruthenium (II) complexes. It was used in a study to reconstitute the α-and β-polypeptides of both Rhodobacter sphaeroides and Rhodospirillum rubrum with bacteriochlorophyll a.
General Description
Hexafluoroacetone trihydrate forms crystalline 1:1 complexes with imidazole 3-oxides.
Synthesis
A spherical fluorinated alumina catalyst (30 g) (particle diameter: 2 to 4 mm) was charged into a reaction tube made of SUS316 (inner diameter: 16 mm, length: 460 mm). The reaction tube was heated to 140° C, and hexafluoro-1,2-epoxypropane (purity: 95%, impurity content: 5% hexafluoropropene) was fed into the reaction tube under the conditions of a feed rate of 50 Nml/min and a total pressure of 3 atmospheres. After 1 hour, the exit gas was analyzed by gas chromatography, with the result that the conversion of hexafluoro-1,2-epoxypropane was 100%. The exit gas was passed into the water, producing crude hexafluoroacetone trihydrate.
References
[1] Sridhar M, et al. A facile method for the preparation of hexafluoroisopropanol functionalized derivatives using hexafluoroacetone trihydrate via a carbonyl-ene reaction. Tetrahedron Letters, 2009; 50: 1777-1779.
[2] K?ster U, et al. Biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227): lack of protein binding of the metabolite hexafluoroacetone. Drug Metabolism and Disposition , 1996.
Hexafluoroacetone trihydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 30 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3958 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18754 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1376 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29885 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8816 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from Hexafluoroacetone trihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-11 | Hexafluoroacetone trihydrate
34202-69-2
|
US $1.00 / Kg | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-02-18 | Hexafluoroacetone trihydrate
34202-69-2
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2022-10-10 | Hexafluoroacetone trihydrate
34202-69-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Hexafluoroacetone trihydrate
34202-69-2
- US $1.00 / Kg
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- Hexafluoroacetone trihydrate
34202-69-2
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- Hexafluoroacetone trihydrate
34202-69-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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