FLLL31
- CAS No.
- 52328-97-9
- Chemical Name:
- FLLL31
- Synonyms
- FLLL31;FLLL31 >=98% (HPLC);Tetramethylcurcumin;FLLL31;FLLL-31;FLLL 31;Tetramethylcurcumin（FLLL31）;Tetramethylcurcumin, 10 mM in DMSO;(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-
- CBNumber:
- CB22731058
- Molecular Formula:
- C25H28O6
- Molecular Weight:
- 424.49
- MDL Number:
- MFCD19443859
- MOL File:
- 52328-97-9.mol
FLLL31 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F9057 | FLLL31 ≥98% (HPLC) | 52328-97-9 | 5mg | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | F9057 | FLLL31 ≥98% (HPLC) | 52328-97-9 | 25mg | $436 | 2024-03-01 | Buy |
| Usbiological | 301048 | Tetramethylcurcumin | 52328-97-9 | 20mg | $665 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259527 | Tetramethylcurcumin 98% | 52328-97-9 | 20mg | $596.7 | 2021-12-16 | Buy |
| ChemScene | CS-0022792 | Tetramethylcurcumin | 52328-97-9 | 5mg | $235 | 2021-12-16 | Buy |
FLLL31 Chemical Properties,Uses,Production
Uses
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].
Biological Activity
Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.
in vitro
Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.
target
| STAT3
|
IC 50
STAT3
References
[1] Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res.?2010 Mar 15;70(6):2445-54. DOI:10.1158/0008-5472.CAN-09-2468
[2] Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol.?2014 Jul;21(1):128-36. DOI:10.1016/j.intimp.2014.04.020
FLLL31 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3978 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13194 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Mensura Group Limited | +8618109034517 | 1058503172@qq.com | China | 2900 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 021-61312847 13636370518 | shyysw007@163.com | China | 4999 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |