ML329
- CAS No.
- 19992-50-8
- Chemical Name:
- ML329
- Synonyms
- ML329;ML329;ML 329;ML-329,ML329,ML 329,Inhibitor,inhibit;4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide;4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide;Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
- CBNumber:
- CB23171697
- Molecular Formula:
- C16H12N2O4S
- Molecular Weight:
- 328.34
- MDL Number:
- MFCD30579194
- MOL File:
- 19992-50-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2935909099 |
ML329 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22481 | ML-329 ≥98% | 19992-50-8 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 22481 | ML-329 ≥98% | 19992-50-8 | 5mg | $145 | 2024-03-01 | Buy |
| Cayman Chemical | 22481 | ML-329 ≥98% | 19992-50-8 | 10mg | $257 | 2024-03-01 | Buy |
| Axon Medchem | Axon2733 | ML329-CID12387471 99% | 19992-50-8 | 10mg | $115.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2733 | ML329-CID12387471 99% | 19992-50-8 | 50mg | $401.5 | 2021-12-16 | Buy |
ML329 Chemical Properties,Uses,Production
Definition
ChEBI: 4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide is a member of 1,4-naphthoquinones.
Biological Activity
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.
in vitro
ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. It could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with it will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. It shows specific activity against the MITF -dependent cells, primary melanocytes but no effect on the viability in A375 cells. It reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, it will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
target
| Target | Value |
| MITF () | |
| TRPM-1 promoter < br/> (Cell-free assay) | 1.2 μM |
ML329 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30236 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4574 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
