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3-TROPANYL-3,5-DICHLOROBENZOATE

3-TROPANYL-3,5-DICHLOROBENZOATE structure

CAS No.: 40796-97-2

Chemical Name:: 3-TROPANYL-3,5-DICHLOROBENZOATE

Synonyms: MDL-72222;MLD-72222;bemesetron;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-TROPANYL-3,5-DICHLOROBENZOATE

CBNumber:: CB2317210

Molecular Formula:: C15H17Cl2NO2

Molecular Weight:: 314.21

MDL Number:: MFCD00865533

MOL File:: 40796-97-2.mol

MSDS File:: SDS

Last updated:2024-11-05 08:26:49

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3-TROPANYL-3,5-DICHLOROBENZOATE Properties

Melting point	165 °C
Boiling point	406.5±45.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	0.1 M HCl: slightly soluble
form	solid
pka	9.89±0.40(Predicted)
color	white
Water Solubility	Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.
FDA UNII	O98T3677PA

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes	T
Risk Statements	25
Safety Statements	36
WGK Germany	3
RTECS	DG7580000

3-TROPANYL-3,5-DICHLOROBENZOATE price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J62583	3-Tropanyl-3,5-dichlorobenzoate, 99+%	40796-97-2	50mg	$247	2021-12-16	Buy
Tocris	0640	MDL72222 ≥99%(HPLC)	40796-97-2	50	$149	2021-12-16	Buy
TRC	M199805	MDL-72222	40796-97-2	100mg	$185	2021-12-16	Buy
Usbiological	255769	MDL 72222	40796-97-2	50mg	$389	2021-12-16	Buy
ApexBio Technology	B6389	MDL72222	40796-97-2	10mg	$189	2021-12-16	Buy

Product number	Packaging	Price	Buy
J62583	50mg	$247	Buy
0640	50	$149	Buy
M199805	100mg	$185	Buy
255769	50mg	$389	Buy
B6389	10mg	$189	Buy

3-TROPANYL-3,5-DICHLOROBENZOATE Chemical Properties,Uses,Production

Originator

Bemesetron,Merrel Dow

Uses

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Uses

Anti-emetic.

Manufacturing Process

Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).

Therapeutic Function

Serotonin antagonist

Biological Activity

5-HT 3 antagonist.

storage

Store at RT

3-TROPANYL-3,5-DICHLOROBENZOATE Preparation Products And Raw materials

Raw materials

Tropine 3,5-Dichlorobenzoyl chloride

Preparation Products

3-TROPANYL-3,5-DICHLOROBENZOATE Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32063	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9640	58
Aromsyn Co., Ltd.	+86-0571-85585865 +8613336024896	CB@aromsyn.com	China	19183	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9649	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58
Aromsyn Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Finetech Industry Limited	58
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58

View Lastest Price from 3-TROPANYL-3,5-DICHLOROBENZOATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-04	Bemesetron 40796-97-2	US $86.00-64.00 / mg		97.37%	10g	TargetMol Chemicals Inc.
	2024-11-04	Bemesetron 40796-97-2	US $86.00-64.00 / mg		97.37%	10g	TargetMol Chemicals Inc.

Bemesetron
40796-97-2
US $86.00-64.00 / mg
97.37%
TargetMol Chemicals Inc.

Bemesetron
40796-97-2
US $86.00-64.00 / mg
97.37%
TargetMol Chemicals Inc.

3-TROPANYL-3,5-DICHLOROBENZOATE Spectrum

3-TROPANYL-3,5-DICHLOROBENZOATE(40796-97-2)¹HNMR

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ENDO-TROPACOCAINE (8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL) BENZOATE HCL 4-BENZYLOXY-PIPERIDINE HYDROCHLORIDE

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3-TROPANYL-3,5-DICHLOROBENZOATE MDL-72222 TROPANYL 3,5-DICHLOROBENZOATE 3,5-dichloro-,8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-benzoicaci 3,5-dichloro-benzoicaci(3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yles bemesetron endo-8-methyl-8-azabicyclo(3.2.1)oct-3-yl3,5-dichlorobenzoate tropyl3,5-dichlorobenzoate tropine 3,5-dichlorobenzoate (1β,5β)-Tropane-3α-ol 3,5-dichlorobenzoate 3,5-Dichlorobenzoic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester Benesetron MLD-72222 Benzoic acid, 3,5-dichloro-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate MNJNPLVXBISNSX-WDNDVIMCSA-N Bemesetron (MDL 72222) Bemesetron (Synonyms: MDL 72222) Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate rel-(1R,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate 40796-97-2 C15H17Cl2NO2 Analytical Standards Analytical Chromatography Product Catalog Forensic and Veterinary Standards Drug Standards Chromatography Serotonin receptor