ChemicalBook >> CAS DataBase List >>JNJ-38877605
JNJ-38877605
- CAS No.
- 943540-74-7
- Chemical Name:
- JNJ-38877605
- Synonyms
- JNJ;OMO-1);JNJ-38877618;JNJ-38877618 (OMO1;Venadaparib Impurity 21;JNJ-38877618,Inhibitor,c-Met/HGFR,JNJ 38877618,JNJ38877618,inhibit;6-[Difluoro[6-(4-pyridinyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline;6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline;Quinoline, 6-[difluoro[6-(4-pyridinyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-
- CBNumber:
- CB24660859
- Molecular Formula:
- C20H12F2N6
- Molecular Weight:
- 374.35
- MDL Number:
- MFCD31657377
- MOL File:
- 943540-74-7.mol
Last updated:2024-07-02 08:55:03
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : 5 mg/mL (13.36 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | E0B2IZB5H5 |
JNJ-38877605 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0034063 | JNJ-38877618 99.01% | 943540-74-7 | 50mg | $910 | 2021-12-16 | Buy |
| ChemScene | CS-0034063 | JNJ-38877618 99.01% | 943540-74-7 | 100mg | $1300 | 2021-12-16 | Buy |
| ChemScene | CS-0034063 | JNJ-38877618 99.01% | 943540-74-7 | 5mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0034063 | JNJ-38877618 99.01% | 943540-74-7 | 10mg | $310 | 2021-12-16 | Buy |
| DC Chemicals | DC21440 | JNJ-38877618 >98% | 943540-74-7 | 100mg | $800 | 2021-12-16 | Buy |
JNJ-38877605 Chemical Properties,Uses,Production
Biological Activity
JNJ-38877618 (OMO-1) is a potent, highly selective, and orally bioavailable Met (c-Met) kinase inhibitor with a Kd of 1.4 nM. Its IC50 values for wild-type Met (c-Met) and mutant Met (c-Met) (M1268T) were 2 nM and 3 nM, respectively.
in vivo
In vivo, JNJ-38877618(OMO-1) completely inhibited tumor growth in 3 tumor models: SNU5 MET amp gastric cancer model, U87-MG HGF autocrine glioblastoma model, and exon 14 skipping deletion mutation Hs746T gastric cancer model of MET gene. Administration of OMO-1 in combination with other drugs is well tolerated and can improve and enhance the effect of EGFR-targeted therapy. Although single-agent OMO-1 has no effect on NSCLC HCC827 EGFR, its combination with erlotinib can delay tumor recurrence.
target
| Target | Value | ||||
| Met (Cell-free assay) | 2 nM | ||||
| MET (M1268T) (Cell-free assay) | 3 nM |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1460 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3257 | 55 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4196 | 55 |
JNJ-38877618
JNJ-38877618
(OMO1
OMO-1)
6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Quinoline, 6-[difluoro[6-(4-pyridinyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-
6-[Difluoro[6-(4-pyridinyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
JNJ-38877618,Inhibitor,c-Met/HGFR,JNJ 38877618,JNJ38877618,inhibit
Venadaparib Impurity 21
JNJ
943540-74-7