AD57 (hydrochloride)
- CAS No.
- 2320261-72-9
- Chemical Name:
- AD57 (hydrochloride)
- Synonyms
- AD57 (hydrochloride);N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride
- CBNumber:
- CB24666215
- Molecular Formula:
- C22H21ClF3N7O
- Molecular Weight:
- 491.8966496
- MDL Number:
- MOL File:
- 2320261-72-9.mol
AD57 (hydrochloride) price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13975 | AD57 (hydrochloride) ≥98% | 2320261-72-9 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 13975 | AD57 (hydrochloride) ≥98% | 2320261-72-9 | 5mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 13975 | AD57 (hydrochloride) ≥98% | 2320261-72-9 | 10mg | $477 | 2024-03-01 | Buy |
| ApexBio Technology | C3080 | AD57(hydrochloride) | 2320261-72-9 | 10mg | $543 | 2021-12-16 | Buy |
| ApexBio Technology | C3080 | AD57(hydrochloride) | 2320261-72-9 | 5mg | $307 | 2021-12-16 | Buy |
AD57 (hydrochloride) Chemical Properties,Uses,Production
Description
Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.1 In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.1 Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.1
References
1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-
AD57 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
AD57 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9941 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 896 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5587 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29978 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |