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BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE structure

CAS No.: 88738-78-7

Chemical Name:: BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE

Synonyms: NSC 634137;METHYL BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE;BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL);METHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE;METHYL P,P-BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE;METHYL O,O'-BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE;Methyl 2-(bis(2,2,2-trifluoroethoxy)-phosphoryl)acetate;Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate 95%;Methyl O,O'-bis(2,2,2-trifluoroethyl)phosphonoacetate,90%;BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETIC ACID METHYL ESTER

CBNumber:: CB2475011

Molecular Formula:: C7H9F6O5P

Molecular Weight:: 318.11

MDL Number:: MFCD00009901

MOL File:: 88738-78-7.mol

MSDS File:: SDS

Last updated:2024-08-15 16:23:59

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BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Properties

Boiling point	246.6±40.0 °C(Predicted)
Density	1.504 g/mL at 25 °C (lit.)
refractive index	n20/D 1.370(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
color	Clear orange to dark orange-brown
Specific Gravity	1.50
BRN	3594044
InChI	InChI=1S/C7H9F6O5P/c1-16-5(14)2-19(15,17-3-6(8,9)10)18-4-7(11,12)13/h2-4H2,1H3
InChIKey	PVSJXEDBEXYLML-UHFFFAOYSA-N
SMILES	C(OC)(=O)CP(OCC(F)(F)F)(OCC(F)(F)F)=O
CAS DataBase Reference	88738-78-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

29319090

NFPA 704

	1
2		0

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	274259	Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate 95%	88738-78-7	5g	$241	2024-03-01	Buy
TCI Chemical	B1714	Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate >95.0%(GC)	88738-78-7	1g	$51	2024-03-01	Buy
TCI Chemical	B1714	Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate >95.0%(GC)	88738-78-7	5g	$174	2024-03-01	Buy
TCI Chemical	B1714	Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate >95.0%(GC)	88738-78-7	25g	$678	2024-03-01	Buy
AK Scientific	Z3375	Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate	88738-78-7	100g	$1601	2021-12-16	Buy

Product number	Packaging	Price	Buy
274259	5g	$241	Buy
B1714	1g	$51	Buy
B1714	5g	$174	Buy
B1714	25g	$678	Buy
Z3375	100g	$1601	Buy

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Chemical Properties,Uses,Production

Chemical Properties

clear orange to dark orange-brown liquid

Uses

Methyl?P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate can be used:

In one of the key synthetic steps for the preparation of?trans-hydrindanes and (R)-(+)-umbelactone.
To prepare a cis-olefinic ester derivative by Still–Gennari olefination of an aldehyde derivative using 18-crown ether and potassium bis(trimethylsilyl)amide (KHMDS).
In the synthesis of (?)-(6S,2′S)-epi?cryptocaryalactone.

Synthesis

The synthesis method of Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl) phosphonate is as follows: To a stirred solution of dried 18-crown-6 (4.53 g, 17.14 mmol), THF (20 mL), and Bis(2,2,2-trifluoroethyl) Phosphite (0.70 mL, 1.29 mmol), was added KHMDS (9.0 mL, 4.50 mmol, 0.5M in toluene) by syringe in a dropwise manner at -78 ℃. After 15 min, methyl chloroacetate (0.30 mL, 3.41 mmol) was added and the reaction mixture was allowed to stir for 4 hr at room temperature. The reaction mixture was diluted with EtOAc (20 mL) and then quenched with sat. ammonium chloride (50 mL). The aqueous layer was extracted with EtOAc (3 x 30 mL). The combined organic extracts were dried under anhydrous magnesium sulfate. Following filtration, the solvents were removed in vacuo. The crude product was then purified by flash column chromatography (33% EtOAc in hexanes, Rf = 0.22 in 33% EtOAc in hexanes) yielding Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate (766 mg, 2.41 mmol, 70.3%) as a yellow syrup.

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE synthesis

Synthesis of BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE from 2,2,2-Trifluoroethanol and Acetic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, methyl ester

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Preparation Products And Raw materials

Raw materials

methylacetylphosphonate Acetic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, methyl ester Acetic acid, 2-(dichlorophosphinyl)-, methyl ester 2,2,2-Trifluoroethanol

Preparation Products

(2E,4E,6Z)-methyl deca-2,4,6-trienoate Propanoic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, methyl ester

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Suppliers

Global( 133)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17453	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10032	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
Accela ChemBio Inc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Fuxin Pharmaceutical	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE 88738-78-7	US $1.00 / KG	1KG	95%	500KG	Career Henan Chemical Co

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE
88738-78-7
US $1.00 / KG
95%
Career Henan Chemical Co

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Spectrum

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE(88738-78-7)MS BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE(88738-78-7)¹HNMR BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE(88738-78-7)¹³CNMR BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE(88738-78-7)IR1 BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE(88738-78-7)Raman

88738-78-7(BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE)Related Search:

TFEC MALONIC ACID BIS(2,4,6-TRICHLOROPHENYL) ESTER BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE Dimethyl 2-hydroxyethylphosphonate PHOSPHONOACETIC ACID

DIETHYL ETHYLPHOSPHONATE DIMETHYL ETHYLPHOSPHONITE DIETHYLPHOSPHONOACETIC ACID Trimethyl phosphonoacetate DIMETHYL ETHYLPHOSPHONATE

Methyl diethylphosphonoacetate Diethyl methylphosphonate Methyldiethoxyphosphine ETHYL METHYLPHOSPHONIC ACID BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE

METHYLPHOSPHONIC ACID ETHYLPHOSPHONIC ACID 2,2,2-TRIFLUOROETHYL TRICHLOROMETHANESULFONATE

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BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETIC ACID METHYL ESTER METHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE METHYL BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE METHYL O,O'-BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE METHYL P,P-BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate 95% Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate95% Methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate, min. 90 % (2-Methoxy-2-oxoethyl)phosphonic acid bis(2,2,2-trifluoroethyl) ester (Methoxycarbonyl)methylphosphonic acid bis(2,2,2-trifluoroethyl) ester [Bis(2,2,2-trifluoroethoxy)phosphinyl]acetic acid methyl ester Methyl O,O'-bis(2,2,2-trifluoroethyl)phosphonoacetate,90% Bis(2,2,2-trifluoroethyl)phosphonoacetic Acid Methyl Ester Methyl [Bis(2,2,2-trifluoroethoxy)phosphinyl]acetate Methyl Bis(2,2,2-trifluoroethyl)phosphonoacetate Methyl 2-(bis(2,2,2-trifluoroethoxy)-phosphoryl)acetate Methyl [bis(2,2,2-trifluoroethoxy)phosphoryl]acetate, Methyl bis(2,2,2-trifluoroethyl)phosphonoacetate Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate 95% NSC 634137 BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL) 4,4,4-trifluoro-2-phosphonato-2-(2,2,2-trifluoroethyl)butanoic acid methyl ester Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate > Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, methyl ester 88738-78-7 CH3O2CCH2POOCH2CF32 C7H9F6O5P Wittig & Horner-Emmons Reaction Horner-Emmons Reaction Olefination Horner-Wadsworth-Emmons Reagents Synthetic Reagents C-C Bond Formation Small molecule Horner-Emmons Reaction Synthetic Organic Chemistry Wittig & Horner-Emmons Reaction