비스(2,2,2-트리플루오로에틸)(메트록시카르보닐메틸)포스포네이트
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비스(2,2,2-트리플루오로에틸)(메트록시카르보닐메틸)포스포네이트 속성
- 끓는 점
- 246.6±40.0 °C(Predicted)
- 밀도
- 1.504 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.370(lit.)
- 인화점
- >230 °F
- 저장 조건
- Inert atmosphere,Room Temperature
- 물리적 상태
- 액체
- 색상
- 투명한 오렌지색부터 짙은 오렌지색 갈색까지
- Specific Gravity
- 1.50
- BRN
- 3594044
- InChI
- InChI=1S/C7H9F6O5P/c1-16-5(14)2-19(15,17-3-6(8,9)10)18-4-7(11,12)13/h2-4H2,1H3
- InChIKey
- PVSJXEDBEXYLML-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)CP(OCC(F)(F)F)(OCC(F)(F)F)=O
- CAS 데이터베이스
- 88738-78-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
비스(2,2,2-트리플루오로에틸)(메트록시카르보닐메틸)포스포네이트 C화학적 특성, 용도, 생산
화학적 성질
clear orange to dark orange-brown liquid용도
Methyl?P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate can be used:- In one of the key synthetic steps for the preparation of?trans-hydrindanes and (R)-(+)-umbelactone.
- To prepare a cis-olefinic ester derivative by Still–Gennari olefination of an aldehyde derivative using 18-crown ether and potassium bis(trimethylsilyl)amide (KHMDS).
- In the synthesis of (?)-(6S,2′S)-epi?cryptocaryalactone.
Synthesis
The synthesis method of Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl) phosphonate is as follows: To a stirred solution of dried 18-crown-6 (4.53 g, 17.14 mmol), THF (20 mL), and Bis(2,2,2-trifluoroethyl) Phosphite (0.70 mL, 1.29 mmol), was added KHMDS (9.0 mL, 4.50 mmol, 0.5M in toluene) by syringe in a dropwise manner at -78 ℃. After 15 min, methyl chloroacetate (0.30 mL, 3.41 mmol) was added and the reaction mixture was allowed to stir for 4 hr at room temperature. The reaction mixture was diluted with EtOAc (20 mL) and then quenched with sat. ammonium chloride (50 mL). The aqueous layer was extracted with EtOAc (3 x 30 mL). The combined organic extracts were dried under anhydrous magnesium sulfate. Following filtration, the solvents were removed in vacuo. The crude product was then purified by flash column chromatography (33% EtOAc in hexanes, Rf = 0.22 in 33% EtOAc in hexanes) yielding Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate (766 mg, 2.41 mmol, 70.3%) as a yellow syrup.비스(2,2,2-트리플루오로에틸)(메트록시카르보닐메틸)포스포네이트 준비 용품 및 원자재
원자재
메틸아세틸포스포네이트
Acetic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, methyl ester
Acetic acid, 2-(dichlorophosphinyl)-, methyl ester
트리플루오로에탄올
준비 용품
비스(2,2,2-트리플루오로에틸)(메트록시카르보닐메틸)포스포네이트 공급 업체
글로벌( 132)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19673 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18623 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29890 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8348 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
비스(2,2,2-트리플루오로에틸)(메트록시카르보닐메틸)포스포네이트 관련 검색:
메틸포스폰산 O,O-다이에틸 메틸포스포나이트 포스포노아세트산 다이에틸 에틸포스폰산 다이에틸 메틸포스폰산 다이메틸 에틸포스포네이트
TFEC
MALONIC ACID BIS(2,4,6-TRICHLOROPHENYL) ESTER
BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE
BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE
ETHYL METHYLPHOSPHONIC ACID
Dimethyl 2-hydroxyethylphosphonate
DIETHYLPHOSPHONOACETIC ACID
DIMETHYL ETHYLPHOSPHONITE
Trimethyl phosphonoacetate
Methyl diethylphosphonoacetate
ETHYLPHOSPHONIC ACID
2,2,2-TRIFLUOROETHYL TRICHLOROMETHANESULFONATE