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Deruxtecan

Deruxtecan structure

CAS No.: 1599440-13-7

Chemical Name:: Deruxtecan

Synonyms: Deruxtecan;MC-GGFG-Exetecan;Deruxtecan analog;Deruxtecan（DX-8951）;Ibandronate Impurity 32;MC-GGFG-Exetecan Deruxtecan analog;Drug-Linker Conjugates for ADC,Inhibitor,inhibit,Deruxtecan;Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-;N-[(S)-10-Benzyl-1-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide;N-((S)-10-Benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

CBNumber:: CB24796642

Molecular Formula:: C52H56FN9O13

Molecular Weight:: 1034.05

MDL Number:: MFCD31657445

MOL File:: 1599440-13-7.mol

Last updated:2024-07-02 08:55:03

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Deruxtecan Properties

Boiling point	1491.1±65.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
solubility	DMSO:67.5(Max Conc. mg/mL);65.28(Max Conc. mM)
pka	11.18±0.40(Predicted)
form	Solid
color	White to yellow
InChIKey	XSLGWYQNBQGZTG-MCZRLCSDSA-N
FDA UNII	5SEB972CO4

Deruxtecan price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0045125	Deruxtecan 99.43%	1599440-13-7	1mg	$750	2021-12-16	Buy
ChemScene	CS-0045125	Deruxtecan 99.43%	1599440-13-7	5mg	$1500	2021-12-16	Buy
ChemScene	CS-0045125	Deruxtecan 99.43%	1599440-13-7	10mg	$1950	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0045125	1mg	$750	Buy
CS-0045125	5mg	$1500	Buy
CS-0045125	10mg	$1950	Buy

Deruxtecan Chemical Properties,Uses,Production

Uses

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

Indications

By Deruxtecan Preparation Trastuzumab deruxtecan drug is approved by the FDA for the treatment of patients with any HER2-positive advanced solid tumour (e.g., breast, gastric, and GOJ adenocarcinomas) and only after the patient has previously received other advanced treatments.

Mechanism of action

Deruxtecan is attached to the antibody by a peptide linker. After trastuzumab deruxtecan binds to HER2 found on malignant cells, it is internalized and linker cleavage occurs through the actions of lysosomal enzymes. After it is released through cleavage, DXd causes targeted DNA damage and apoptosis in cancer cells, due to the ability to cross cell membranes.

Side effects

The most common side effects of Deruxtecan (Trastuzumab deruxtecan) include: nausea, vomiting, diarrhoea, fatigue, hair loss, increased risk of infections (low white blood cell counts, red blood cell counts, and platelet counts), breathlessness, coughing, headache, bone or muscle pain, mouth ulcers, loss of appetite, weight loss, heart problems, liver or skin changes, low potassium levels. All of these side effects may not always occur at the same time and will vary from person to person. Serious adverse reactions include: interstitial lung disease/pneumonia, serious impairment of heart function and allergic reactions. Special care should be taken to contact your doctor in case of any serious adverse reactions.

Deruxtecan Preparation Products And Raw materials

Raw materials

Preparation Products

Deruxtecan Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xilinglab Co., Ltd.	+8618381337976	bd@xilinglab.com	China	86	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7287	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9626	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58

Supplier	Advantage
Xilinglab Co., Ltd.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Chengdu Pukang Biotechnology Co., Ltd	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Finetech Industry Limited	58
Shenzhen Shengda Pharma Limited	58

View Lastest Price from Deruxtecan manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-10-14	Deruxtecan 1599440-13-7	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2022-03-07	Deruxtecan 1599440-13-7	US $4666.00 / mg/bottle	100mg/bottle	99%	10kg	Shenzhen Shengda Pharma Limited

Deruxtecan
1599440-13-7
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Deruxtecan
1599440-13-7
US $4666.00 / mg/bottle
99%
Shenzhen Shengda Pharma Limited

1599440-13-7(Deruxtecan)Related Search:

Deruxtecan

Deruxtecan analog Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]- MC-GGFG-Exetecan Deruxtecan Deruxtecan（DX-8951） N-((S)-10-Benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide Drug-Linker Conjugates for ADC,Inhibitor,inhibit,Deruxtecan Ibandronate Impurity 32 N-[(S)-10-Benzyl-1-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide MC-GGFG-Exetecan Deruxtecan analog N-((S)-10-Benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide 1599440-13-7 C52H56FN9O13 Pharmaceutical API ADC