デルクステカン

デルクステカン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

デルクステカン 化学特性,用途語,生産方法

使用

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

適応症

By Deruxtecan Preparation Trastuzumab deruxtecan drug is approved by the FDA for the treatment of patients with any HER2-positive advanced solid tumour (e.g., breast, gastric, and GOJ adenocarcinomas) and only after the patient has previously received other advanced treatments.

作用機序

Deruxtecan is attached to the antibody by a peptide linker. After trastuzumab deruxtecan binds to HER2 found on malignant cells, it is internalized and linker cleavage occurs through the actions of lysosomal enzymes. After it is released through cleavage, DXd causes targeted DNA damage and apoptosis in cancer cells, due to the ability to cross cell membranes.

副作用

The most common side effects of Deruxtecan (Trastuzumab deruxtecan) include: nausea, vomiting, diarrhoea, fatigue, hair loss, increased risk of infections (low white blood cell counts, red blood cell counts, and platelet counts), breathlessness, coughing, headache, bone or muscle pain, mouth ulcers, loss of appetite, weight loss, heart problems, liver or skin changes, low potassium levels. All of these side effects may not always occur at the same time and will vary from person to person. Serious adverse reactions include: interstitial lung disease/pneumonia, serious impairment of heart function and allergic reactions. Special care should be taken to contact your doctor in case of any serious adverse reactions.

デルクステカン 上流と下流の製品情報

原材料

準備製品

デルクステカン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Xilinglab Co., Ltd.	+8618381337976	bd@xilinglab.com	China	86	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7287	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9626	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58

1599440-13-7(デルクステカン)キーワード:

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• 1599440-13-7
• Deruxtecan analog
• Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-
• MC-GGFG-Exetecan
• Deruxtecan
• Deruxtecan（DX-8951）
• N-((S)-10-Benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
• Drug-Linker Conjugates for ADC,Inhibitor,inhibit,Deruxtecan
• Ibandronate Impurity 32
• N-[(S)-10-Benzyl-1-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
• MC-GGFG-Exetecan Deruxtecan analog
• N-((S)-10-Benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
• 6-(2,5-ジオキソ-2,5-ジヒドロ-1H-ピロール-1-イル)-N-{[({[(1S)-1-[({[({[(10S,23S)-10-エチル-18-フルオロ-10-ヒドロキシ-19-メチル-5,9-ジオキソ-8-オキサ-4,15-ジアザヘキサシクロ[14.7.1.02,14.04,13.06,11.020,24]テトラコサ-1(24),2(14),6(11),12,15,17,19-ヘプタエン-23-イル]カルバモイル}メトキシ)メチル]カルバモイル}メチル)カルバモイル]-2-フェニルエチル]カルバモイル}メチル)カルバモイル]メチル}ヘキサンアミド
• 6-(2,5-ジオキソピロール-1-イル)-N-{[({[(1S)-1-[({[({[(10S,23S)-10-エチル-18-フルオロ-10-ヒドロキシ-19-メチル-5,9-ジオキソ-8-オキサ-4,15-ジアザヘキサシクロ[14.7.1.02,14.04,13.06,11.020,24]テトラコサ-1(24),2(14),6(11),12,15,17,19-ヘプタエン-23-イル]カルバモイル}メトキシ)メチル]カルバモイル}メチル)カルバモイル]-2-フェニルエチル]カルバモイル}メチル)カルバモイル]メチル}ヘキサンアミド
• デルクステカン