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4-Chloro-3,5-dimethylphenol

4-Chloro-3,5-dimethylphenol Structure
4-Chloro-3,5-dimethylphenol structure
CAS No.
88-04-0
Chemical Name:
4-Chloro-3,5-dimethylphenol
Synonyms
PCMX;CHLOROXYLENOL;4-CHLORO-3,5-XYLENOL;Para-chloro-meta-xylenol;Dettol;nipacidemx;P-CHLORO-M-XYLENOL;Dimethyl-4-chlorophenol;Camel;rba777
CBNumber:
CB2666624
Molecular Formula:
C8H9ClO
Molecular Weight:
156.61
MDL Number:
MFCD00002324
MOL File:
88-04-0.mol
Last updated:2024-11-19 20:33:22
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4-Chloro-3,5-dimethylphenol Properties

Melting point 114-116 °C(lit.)
Boiling point 246 °C
Density 0.67 g/cm3
refractive index 1.5523 (estimate)
Flash point 132 °C
storage temp. 2-8°C
solubility methanol: soluble1g/10 mL, clear to faintly turbid, colorless to very faintly yellow
pka 9.76±0.23(Predicted)
form Crystalline Powder or Crystals
color White to light beige
PH 7 (0.2g/l, H2O)
Odor wh. cryst. or cryst. powd., char. phenolic odor
Water Solubility 0.3 g/L (20 ºC)
Merck 14,2176
BRN 1862539
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey OSDLLIBGSJNGJE-UHFFFAOYSA-N
LogP 3.270
Indirect Additives used in Food Contact Substances CHLOROXYLENOL
FDA 21 CFR 175.105; 310.545
CAS DataBase Reference 88-04-0(CAS DataBase Reference)
EWG's Food Scores 3
FDA UNII 0F32U78V2Q
ATC code D08AE05
NIST Chemistry Reference Chloroxylenol(88-04-0)
EPA Substance Registry System 4-Chloro-3,5-dimethylphenol (88-04-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-43
Safety Statements  24-37
RIDADR  UN 3077 9/PG 3
WGK Germany  1
RTECS  ZE6850000
Hazard Note  Irritant
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29081000
Toxicity LD50 orally in Rabbit: 3830 mg/kg
NFPA 704
0
2 0

4-Chloro-3,5-dimethylphenol price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich BP080 Chloroxylenol British Pharmacopoeia (BP) Reference Standard 88-04-0 500MG $220 2024-03-01 Buy
Sigma-Aldrich 8.18734 4-Chloro-3,5-dimethylphenol for synthesis 88-04-0 250g $57.5 2024-03-01 Buy
Sigma-Aldrich 24380 4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T) 88-04-0 1kg $74.8 2024-03-01 Buy
Sigma-Aldrich 1122700 Chloroxylenol United States Pharmacopeia (USP) Reference Standard 88-04-0 125mg $161.2 2024-03-01 Buy
Sigma-Aldrich 24380 4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T) 88-04-0 50g $27.4 2023-06-20 Buy
Product number Packaging Price Buy
BP080 500MG $220 Buy
8.18734 250g $57.5 Buy
24380 1kg $74.8 Buy
1122700 125mg $161.2 Buy
24380 50g $27.4 Buy

4-Chloro-3,5-dimethylphenol Chemical Properties,Uses,Production

Chemical Properties

White or cream-colored crystals or crystalline powder with a characteristic phenolic odor. Volatile in steam.

Chemical Properties

4-Chloro-3,5-dimethylphenol is white or cream crystalline powder with a characteristic odour

Originator

Septiderm ,Fougera ,US,1960

Uses

antibacterial, topical and urinary antiseptic

Uses

Antiseptic and germicide; for mildew prevention. Claimed to be about 60 times as potent as phenol.

Uses

4-Chloro-3,5-dimethylphenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).

Definition

ChEBI: 4-chloro-3,5-dimethylphenol is a member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores. It has a role as an antiseptic drug, a disinfectant and a molluscicide. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to a 3,5-xylenol.

Production Methods

Chloroxylenol is prepared by treating 3,5-dimethylphenol with chlorine or sulfuryl chloride (SO2Cl2).

Manufacturing Process

546 g of intermediate xylenol fraction having a crystallizing point of 45°C mixed with an equal weight of m-5-xylenol are placed in a suitable vessel, equipped with stirring gear, and 273 g of sulfuryl chloride are added slowly. The temperature rises in the course of the reaction to about 40°C. When all the sulfuryl chloride is added the reaction mixture is heated to 80°C and theacid gases removed as far as possible by air-blowing or any other suitable means. On cooling a quantity of the required chlor-xylenol separates out and is removed from the mother liquor. Further quantities of the material required can be isolated by vacuum distillation of the mother liquors and further crystallization. In all, 200 to 208 g of material substantially 2-chlor-m-5- xylenol can be obtained having a melting point of 112°C to 115°C. The material can be purified if desired by crystallization from a solvent such as a hydrocarbon.

Therapeutic Function

Topical antiseptic; Disinfectant

General Description

The degradation of 4-chloro-3,5-dimethylphenol (PCMX) by Fenton-like process using nanoparticulate zero-valent iron (nZVI) and hydrogen peroxide (H2O2) was studied.

Pharmaceutical Applications

4-Chloro-3,5-dimethylphenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection.
As a pharmaceutical excipient, 4-Chloro-3,5-dimethylphenol is commonly used in low concentrations as an antimicrobial preservative in topical formulations such as creams and ointments. 4-Chloro-3,5-dimethylphenol is also used in a number of cosmetic formulations.
Therapeutically, 4-Chloro-3,5-dimethylphenol has been investigated as a treatment for acne vulgaris, for treating infected root canals, and as an antifungal agent when impregnated into medical devices. 4-Chloro-3,5-dimethylphenol is included in drug products approved for topical antifungal, topical acne and topical dandruff/seborrheic dermatitis/psoriasis treatments.

Agricultural Uses

Microbiocide: 4-Chloro-3,5-dimethylphenol was first registered in the U.S. for use as a fungicide and is now applied as an antimicrobial for control of bacteria, algae and fungi in adhesives, emulsions, paints and wash tanks. It is registered for use in household and domestic dwellings, laundry equipment, bathrooms, diaper pails and in industrial water and aqueous systems. Not listed for use in EU countries. Registered for use in the U.S. There are 64 global suppliers.

Trade name

BAR-FUNGAL PLUS®[C]; BIO SLIME®[C]; DESSON®; DETTOL®; ECOTRU®; ESPADOL®; HUSEPT®; HUSEPT EXTRA®; NIPACIDE®; OTTASEPT®[C]; OTTASEPT® EXTRA[C]; PCMX; RBA 777®

Clinical Use

p-Chloro-m-xylenol (PC-MX; Metasep) is a nonirritating antiseptic agent with broad-spectrum antibacterial and antifungal properties. It is marketed in a 2% concentration as a shampoo. It has also been used topically for the treatment of tinea (ringworm) infections such as athlete s foot (tinea pedis) and jock itch (tinea cruris).

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. An eye irritant. An antimicrobial agent. See also CHLOROPHENOLS and CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic fumes of Cl-.

Safety

Chloroxylenol is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient in topical products. However, chloroxylenol has been placed in Toxicity Category I for eye irritation effects. In addition, allergic skin reactions have been reported. Taken orally, chloroxylenol is mildly toxic and ingestion of a chloroxylenol-containing disinfectant product has been associated with reports of fatal or severe instances of selfpoisoning.
LD50 (mouse, IP): 0.115 g/kg
LD50 (rat, dermal): >2.0 g/kg
LD50 (rat, oral): 3.83 g/kg

storage

Chloroxylenol is stable at normal room temperature, but is volatile in steam. Contact with natural rubber should be avoided. Aqueous solutions of chloroxylenol are susceptible to microbial contamination and appropriate measures should be taken to prevent contamination during storage or dilution. Chloroxylenol should be stored in polyethylene, mild steel or stainless steel containers, which should be well-closed and kept in a cool, dry place. Chloroxylenol does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours.

Purification Methods

Crystallise the phenol from *benzene or toluene. [Beilstein 6 IV 3152.]

Incompatibilities

4-Chloro-3,5-dimethylphenol has been reported to be incompatible with nonionic surfactants and methylcellulose.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic preparations; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK. Approved in Europe as a preservative in cosmetics with a maximum authorized concentration of 0.5%.

4-Chloro-3,5-dimethylphenol synthesis

108-68-9
88-04-0
Synthesis of 4-Chloro-3,5-dimethylphenol from 3,5-Dimethylphenol

4-Chloro-3,5-dimethylphenol Preparation Products And Raw materials

Raw materials

ZINC Xylenol Sulfuryl chloride CHLOROXYLENOL RELATED COMPOUND A (25 MG) (2- CHLORO-3,5-DIMETHYLPHENOL) 2,4-Dichloro-3,5-dimethylphenol
3,5-Dimethylphenol Chloroform

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Preparation Products

4-Chloro-3,5-dimethylphenol Suppliers

Global( 631)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887 sales@finerchem.com China 2963 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5892 58
Hebei Dangtong Import and export Co LTD 		+86-13910575315 +86-13910575315 admin@hbdangtong.com China 1000 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18153 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Sigma Audley 		+86-15937194204 +86-18126314766 nova@sh-teruiop.com China 467 58
Supplier Advantage
Jinan Finer Chemical Co., Ltd
58
Hefei TNJ Chemical Industry Co.,Ltd.
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Dangtong Import and export Co LTD 		58
Hebei Weibang Biotechnology Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Sigma Audley 		58

Related articles

View Lastest Price from 4-Chloro-3,5-dimethylphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-3,5-dimethylphenol pictures 2024-11-28 4-Chloro-3,5-dimethylphenol
88-04-0
 US $6.00 / kg 1kg More than 99% 2000KG/Month Hebei Longbang Technology Co., Ltd
4-Chloro-3,5-dimethylphenol pictures 2024-11-28 4-Chloro-3,5-dimethylphenol
88-04-0
 US $10.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
4-Chloro-3,5-dimethylphenol pictures 2024-11-28 4-Chloro-3,5-dimethylphenol
88-04-0
 US $6.00 / kg 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd

4-Chloro-3,5-dimethylphenol Spectrum

4-Chloro-3,5-dimethylphenol(88-04-0)MS4-Chloro-3,5-dimethylphenol(88-04-0)1HNMR4-Chloro-3,5-dimethylphenol(88-04-0)13CNMR4-Chloro-3,5-dimethylphenol(88-04-0)IR14-Chloro-3,5-dimethylphenol(88-04-0)IR24-Chloro-3,5-dimethylphenol(88-04-0)Raman

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Dettol, liquid antiseptic Espadol Husept extra huseptextra Nipacide mx Nipacide PX Ottasept Ottasept extra ottaseptextra Parametaxylenol p-Chloro-3,5-xylenol p-chloro-m-xylenol-phenol Phenol, 4-chloro-3,5-dimethyl- Rba 777 rba777 Septiderm-hydrochloride Willenol V Xylenol, 4-chloro- 2-Chloro-m-xylenol 3,5-Xylenol, 4-chloro- 4-CHLORO-META-XYLENOL 4-CHLORO-3,5-XYLENOL 99+% 27) PARA CHLORO META XYLENOL 4-Chloro-3,5-diMethylphenol puruM, >=98.0% (T) Between the chlorine diMethyl phenol 4-Chloro-3.5-d 2,6-DiMethyl-4-hydroxy-1-chlorobenzene 4-Chloro-5,3-diMethylphenol 4 chloro 3,5 diMethylphenol p-Chloro-M-xylenol Chloro-3,5-diMethylp P-Chloro-M-Xylenol (PCMX), 4-Chloro-3,5-diMethylphenol Dett germicide 4-Chloro-3,5-dimethylphenol, 98+% 4-Chloro-3,5-dimethylphenol,99% 4-Chloro-3,5-dimethylphenol,4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol Chloroxylenol (125 mg) 4-Chloro-3,5-dimethy 4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol 4-Chloro-3,5-diMethylphenol, 99% 100GR Ayrtol Benzytol Camel Chloro-3,5-dimethylphenol Chloro-3,5-xylenol Chloro-5-hydroxy-m-xylene Chloro-m-xylenol Chloroxylend Desson BENZYLTOL CHLORO-SYM-XYLENOL 3,5-DIMETHYL-4-CHLORO PHENOL 4-CHLORO-3,5-DIMETHYLPHENOL 4-CHLORO-SYM-M-XYLENOL 4-Chloro-1-hydroxy-3,5-dimethylbenzene 4-chloro-3,5-dimethyl-pheno 4-Chloro-3,5-xylenol GL 4-Chloro-3-xylenol 4-chloro-5-xylenol