4-클로로-3,4-디메틸페놀
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4-클로로-3,4-디메틸페놀 속성
- 녹는점
- 114-116 °C(lit.)
- 끓는 점
- 246 °C
- 밀도
- 0.67 g/cm3
- 굴절률
- 1.5523 (estimate)
- 인화점
- 132 °C
- 저장 조건
- 2-8°C
- 용해도
- 메탄올: 가용성 1g/10mL, 투명하거나 희미하게 혼탁함, 무색 내지 매우 희미한 노란색
- 산도 계수 (pKa)
- 9.76±0.23(Predicted)
- 물리적 상태
- 결정질 분말 또는 결정
- 색상
- 흰색~밝은 베이지
- 수소이온지수(pH)
- 7 (0.2g/l, H2O)
- 냄새
- wh. cryst. or cryst. powd., char. phenolic odor
- 수용성
- 0.3g/L(20℃)
- Merck
- 14,2176
- BRN
- 1862539
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- OSDLLIBGSJNGJE-UHFFFAOYSA-N
- LogP
- 3.270
- CAS 데이터베이스
- 88-04-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/38-43 | ||
안전지침서 | 24-37 | ||
유엔번호(UN No.) | UN 3077 9/PG 3 | ||
WGK 독일 | 1 | ||
RTECS 번호 | ZE6850000 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
위험 등급 | 9 | ||
포장분류 | III | ||
HS 번호 | 29081000 | ||
유해 물질 데이터 | 88-04-0(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 3830 mg/kg | ||
기존화학 물질 | KE-05943 |
4-클로로-3,4-디메틸페놀 C화학적 특성, 용도, 생산
화학적 성질
4-Chloro-3,5-dimethylphenol is white or cream crystalline powder with a characteristic odour용도
4-Chloro-3,5-dimethylphenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).생산 방법
Chloroxylenol is prepared by treating 3,5-dimethylphenol with chlorine or sulfuryl chloride (SO2Cl2).일반 설명
The degradation of 4-chloro-3,5-dimethylphenol (PCMX) by Fenton-like process using nanoparticulate zero-valent iron (nZVI) and hydrogen peroxide (H2O2) was studied.Pharmaceutical Applications
4-Chloro-3,5-dimethylphenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection.As a pharmaceutical excipient, 4-Chloro-3,5-dimethylphenol is commonly used in low concentrations as an antimicrobial preservative in topical formulations such as creams and ointments. 4-Chloro-3,5-dimethylphenol is also used in a number of cosmetic formulations.
Therapeutically, 4-Chloro-3,5-dimethylphenol has been investigated as a treatment for acne vulgaris, for treating infected root canals, and as an antifungal agent when impregnated into medical devices. 4-Chloro-3,5-dimethylphenol is included in drug products approved for topical antifungal, topical acne and topical dandruff/seborrheic dermatitis/psoriasis treatments.
농업용
Microbiocide: 4-Chloro-3,5-dimethylphenol was first registered in the U.S. for use as a fungicide and is now applied as an antimicrobial for control of bacteria, algae and fungi in adhesives, emulsions, paints and wash tanks. It is registered for use in household and domestic dwellings, laundry equipment, bathrooms, diaper pails and in industrial water and aqueous systems. Not listed for use in EU countries. Registered for use in the U.S. There are 64 global suppliers.상품명
BAR-FUNGAL PLUS®[C]; BIO SLIME®[C]; DESSON®; DETTOL®; ECOTRU®; ESPADOL®; HUSEPT®; HUSEPT EXTRA®; NIPACIDE®; OTTASEPT®[C]; OTTASEPT® EXTRA[C]; PCMX; RBA 777®Clinical Use
p-Chloro-m-xylenol (PC-MX; Metasep) is a nonirritating antiseptic agent with broad-spectrum antibacterial and antifungal properties. It is marketed in a 2% concentration as a shampoo. It has also been used topically for the treatment of tinea (ringworm) infections such as athlete s foot (tinea pedis) and jock itch (tinea cruris).Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. An eye irritant. An antimicrobial agent. See also CHLOROPHENOLS and CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic fumes of Cl-.Safety
Chloroxylenol is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient in topical products. However, chloroxylenol has been placed in Toxicity Category I for eye irritation effects. In addition, allergic skin reactions have been reported. Taken orally, chloroxylenol is mildly toxic and ingestion of a chloroxylenol-containing disinfectant product has been associated with reports of fatal or severe instances of selfpoisoning.LD50 (mouse, IP): 0.115 g/kg
LD50 (rat, dermal): >2.0 g/kg
LD50 (rat, oral): 3.83 g/kg
저장
Chloroxylenol is stable at normal room temperature, but is volatile in steam. Contact with natural rubber should be avoided. Aqueous solutions of chloroxylenol are susceptible to microbial contamination and appropriate measures should be taken to prevent contamination during storage or dilution. Chloroxylenol should be stored in polyethylene, mild steel or stainless steel containers, which should be well-closed and kept in a cool, dry place. Chloroxylenol does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours.Purification Methods
Crystallise the phenol from *benzene or toluene. [Beilstein 6 IV 3152.]비 호환성
4-Chloro-3,5-dimethylphenol has been reported to be incompatible with nonionic surfactants and methylcellulose.Regulatory Status
Included in the FDA Inactive Ingredients Database (otic preparations; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK. Approved in Europe as a preservative in cosmetics with a maximum authorized concentration of 0.5%.4-클로로-3,4-디메틸페놀 준비 용품 및 원자재
원자재
아연
자일렌올 (혼합 이성질체)
염화설퍼릴
클로로자일레놀관련화합물A(25MG)(2-클로로-3,5-디메틸페닐페놀)
2,4-Dichloro-3,5-dimethylphenol
3,5-자일렌올
클로로포름
준비 용품
4-클로로-3,4-디메틸페놀 공급 업체
글로벌( 620)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2966 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 |
admin@hbdangtong.com | China | 1005 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Shandong Juchuang Chemical Co., LTD | +undefined15030412209 |
admin@juchuangchem.com | China | 387 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
4-클로로-3,4-디메틸페놀 관련 검색:
클로로디메틸비닐실란 자일렌올 (혼합 이성질체) 에피클로로하이드린 4-클로로-m-크레졸 p-클로로페놀 터트-뷰틸클로로다이메틸실란 2,5-자일렌올 M-클로로페놀 3,5-자일렌올 클로로아세트산 클로로디플루오르메탄 3-자일렌 4-클로로-3,4-디메틸페놀
DIMETHYLTHEXYLSILYL CHLORIDE
Chlorodimethylphenylsilane
2,4,6-trichloro-3,5-dimethylphenol
2,4-Dichloro-3,5-dimethylphenol
2,6-DIBROMO-4-CHLORO-3,5-DIMETHYLPHENOL