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Adefovir

CAS No.
106941-25-7
Chemical Name:
Adefovir
Synonyms
PMEA;GS-393;gs0393;Adefovi;ADEFOVIR;A Duff Vee;Adefovir98%;Adefovir API;adefovir ,97%;Adefovir(PMEA)
CBNumber:
CB2698137
Molecular Formula:
C8H12N5O4P
Molecular Weight:
273.19
MDL Number:
MFCD00866943
MOL File:
106941-25-7.mol
MSDS File:
SDS
Last updated:2024-10-28 16:48:35

Adefovir Properties

Melting point >260°C
Boiling point 632.5±65.0 °C(Predicted)
Density 1.88
storage temp. -20°C
solubility 0.1 M NaOH: ≥5mg/mL
pka pKa1 2.0, pKa2 6.8(at 25℃)
form powder
color white to beige
InChIKey SUPKOOSCJHTBAH-UHFFFAOYSA-N
CAS DataBase Reference 106941-25-7(CAS DataBase Reference)
FDA UNII 6GQP90I798

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  2811
WGK Germany  3
RTECS  SZ6563500
HazardClass  6.1
PackingGroup 
HS Code  29339900
Hazardous Substances Data 106941-25-7(Hazardous Substances Data)
NFPA 704
0
2 0

Adefovir price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0240 Adefovir ≥98% (HPLC) 106941-25-7 10mg $110 2024-03-01 Buy
Sigma-Aldrich SML0240 Adefovir ≥98% (HPLC) 106941-25-7 50mg $441 2024-03-01 Buy
Cayman Chemical 18650 Adefovir ≥95% 106941-25-7 10mg $32 2024-03-01 Buy
Cayman Chemical 18650 Adefovir ≥95% 106941-25-7 50mg $139 2024-03-01 Buy
Cayman Chemical 18650 Adefovir ≥95% 106941-25-7 100mg $243 2024-03-01 Buy
Product number Packaging Price Buy
SML0240 10mg $110 Buy
SML0240 50mg $441 Buy
18650 10mg $32 Buy
18650 50mg $139 Buy
18650 100mg $243 Buy

Adefovir Chemical Properties,Uses,Production

Description

Adefovir (Trade name: Preveon, Hepsera) is a prescription drug used for the treatment of chronic infections of hepatitis B virus. It can be formulated as the pivoxil prodrug adefovir dipivoxil. However, it shows no effect against HIV-1. As a orally administrated acyclic nucleotide analog reverse transcriptase inhibitor, it blocking the reproduction of HBV through inhibiting the reverse transcriptase in the body. One of its advantages over another anti-HBV drug, lamivudine is that it is much harder for the virus to develop resistance to it.

References

https://www.drugbank.ca/drugs/DB00718
http://en.wikipedia.org/wiki/Adefovir

Chemical Properties

Pale Brown Solid

Uses

Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.

Uses

Used as an antiviral

Definition

ChEBI: Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir(1-).

Acquired resistance

It has a lower propensity to induce drug resistance than lamivudine. Clinical trials of patients receiving 48 weeks of therapy did not identify any cases of resistance. Longer courses yield resistant strains of HBV with mutations in the DNA polymerase gene; other rare variants of resistant strains have been identified. Lamivudine-resistant strains of HBV retain susceptibility to adefovir.

Pharmaceutical Applications

A nucleotide analog of adenosine monophosphate, administered orally as its prodrug, adefovir dipivoxil.

Biochem/physiol Actions

Adefovir is an antiviral drug that after intracellular conversion to adefovir diphosphate inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase).

Pharmacokinetics

Oral absorption: c. 60%
Cmax 10 mg/kg oral: 18.4 ng/mL
Plasma half-life: c. 7.5 h.
Volume of distribution: 392 mL/kg
Plasma protein binding: Not known
The prodrug is metabolized to adefovir, which is excreted by the kidneys and therefore requires dose adjustment in patients with impaired renal function. It does not induce cytochrome P450 at standard doses and does not influence the metabolism or plasma concentrations of the other licensed medications used in the treatment of hepatitis B.

Clinical Use

Treatment of chronic hepatitis B virus infection in patients >12 years of age

Side effects

It is generally well tolerated, with headache, pharyngitis, abdominal pain and peripheral neuropathy being the most common side effects. Nephrotoxicity has been observed in some patients, with those receiving higher doses and longer courses of therapy at greater risk. Exacerbation of hepatitis has been reported in patients immediately following discontinuation of treatment. Most exacerbations occur within 12 weeks of stopping therapy, and elevations of alanine aminotransferase (ALT) up to 10 times the upper limit of normal can be observed in over 25% of patients. Lactic acidosis has been reported in a few patients and is an indication for immediate discontinuation.

116384-53-3
106941-25-7
Synthesis of Adefovir from [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

Adefovir Preparation Products And Raw materials

Global( 401)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5857 58
airuikechemical co., ltd.
+undefined86-15315557071 sales02@sdzhonghuimaterial.com China 983 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902 angelia@hbmojin.com China 1176 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58

View Lastest Price from Adefovir manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Adefovir pictures 2024-12-23 Adefovir
106941-25-7
US $0.00-0.00 / KG 1KG 99% 20TONS Sinoway Industrial co., ltd.
Adefovir pictures 2024-12-13 Adefovir
106941-25-7
US $0.00-0.00 / Kg/Drum 1KG 99%min HPLC 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Adefovir pictures 2024-10-28 Adefovir
106941-25-7
US $0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
  • Adefovir pictures
  • Adefovir
    106941-25-7
  • US $0.00-0.00 / KG
  • 99%
  • Sinoway Industrial co., ltd.
  • Adefovir pictures
  • Adefovir
    106941-25-7
  • US $0.00-0.00 / Kg/Drum
  • 99%min HPLC
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Adefovir pictures
  • Adefovir
    106941-25-7
  • US $0.00 / KG
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd

Adefovir Spectrum

2-(6-amino-9h-purin- Adefovir dipivox (PMEA) [[2-(6-AMino-9H-purin-9-yl)ethoxy] Methyl]phosponic Acid P-[[2-(6-AMino-9H-purin-9-yl)ethoxy]Methyl]phosphonic Acid Adefovir(PMEA) Adefovir98% [({[2-(6-aMino-9H-purin-9-yl)ethoxy]Methyl}({[(2,2-diMethylpropanoyl)oxy]Methoxy})phosphoryl)oxy]Methyl 2,2-diMethylpropanoate A Duff Vee Adefovir API GS-393 P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine 2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonic acid Adefovir(PMEA) Adefovir Dipivoxil Impurity (Adefovir) 2-(6-amino-9h-purin-9-yl)ethoxy]methylphosphonic acid 9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE 9-(2-PHOSPHONYL METHOXY ETHYL) ADENINE ADEFOVIR PMEA ((2-(6-amino-9h-purin-9-yl)ethoxy)methyl)-phosphonicaci 9-[2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonicacid [[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphonic acid (PMEA) PMEA([[2-(6-amino-9H-purin-9-yl) 9-[2- (phosphonomethoxy) ethyl] adenine, alternate name adefovir[PMEA] [2-(6-Amino-9H-purine-9-yl)ethoxymethyl]phosphonic acid Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- (9CI) 9-[2-(6-Amino-9H-purin-9-yl)et Adefovir & Adefovir Dipivoxil gs0393 adefovir ,97% 9-[2-[bis(pivaloyloxymethoxy)phosphorylmethoxyl]ethyl]adenine 9-(2-Phosphonomethoxy Etheyl) Adenine 9-(2-PHOSPHORYL METHOXYL ETHYL) ADENINE 9-(2-(2-phosphoromethoxy)ethyl adenine (PMEA) Adefovir dipivoxil intermediate B 2-(6-AMINO-9H-OUR IN-9-YL)ETHOXY]METHYLPHOSPHONIC ACID 9-[2-phosphonylmethoxyethyl]ad Adefovir,9-[2-phosphonylmethoxyethyl]adenine 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE(ADEFOVIR) [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosponicAcid,PMEA,GS-393, treatment Adefovir Tenofovir Desmethyl Impurity Adefovi Phosphonic acid, P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- Adefovir USP/EP/BP Adefovir (GS-0393) AdefovirQ: What is Adefovir Q: What is the CAS Number of Adefovir Q: What is the storage condition of Adefovir Q: What are the applications of Adefovir 3-Di-o-tolylguanidine 2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid 106941-25-7 C8H12N5O4P C8H14N5O4P C8H13N5O4P Other Products Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals