CETABEN
- CAS No.
- 55986-43-1
- Chemical Name:
- CETABEN
- Synonyms
- CETABEN;Peroxisome Proliferator, Cetaben;Benzoic acid, 4-(hexadecylamino)-;HEXADECYLAMINO-P-AMINO BENZOIC ACID;proliferator,peroxisome,cholesterol,exceptional,triglycerides,Inhibitor,Cetaben,inhibit,non-fibrate,hypolipidemic,PPARα,drug
- CBNumber:
- CB2752657
- Molecular Formula:
- C23H39NO2
- Molecular Weight:
- 361.56
- MDL Number:
- MFCD00865766
- MOL File:
- 55986-43-1.mol
Boiling point | 503.4±33.0 °C(Predicted) |
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Density | 0.979±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 4.76±0.10(Predicted) |
color | White to off-white |
FDA UNII | DTL5W0113X |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
NFPA 704 |
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CETABEN price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10007171 | Cetaben ≥98% | 55986-43-1 | 5mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 10007171 | Cetaben ≥98% | 55986-43-1 | 10mg | $66 | 2024-03-01 | Buy |
Cayman Chemical | 10007171 | Cetaben ≥98% | 55986-43-1 | 50mg | $274 | 2024-03-01 | Buy |
Cayman Chemical | 10007171 | Cetaben ≥98% | 55986-43-1 | 100mg | $477 | 2024-03-01 | Buy |
American Custom Chemicals Corporation | CHM0150365 | 4-(HEXADECYLAMINO)-BENZOIC ACID 95.00% | 55986-43-1 | 5MG | $500.09 | 2021-12-16 | Buy |
CETABEN Chemical Properties,Uses,Production
Uses
Antihyperlipoproteinemic.
Biological Activity
cetaben is an unique pparα-independent peroxisome proliferator.the fibrate class of hypolipidemic drugs, such as fenofibrate and clofibrate, elicit their effects via binding to and activating peroxisome proliferator-activated receptor α (pparα).
in vitro
previous study showed that cetaben could cause little but reversible proliferation and morphological heterogeneity with the occurrence of dumbbell- and cup-shaped peroxisomal profiles. peroxisomes in hepg2 cells showed marked variation in size and shape. cetaben treatment of hepg2 cells was able to lead to disintegration of golgi regions and augmented mitochondrial matrix [1].
in vivo
animal study found that the changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of both cetaben and clofibric acid 200 mg/kg/day to male wistar rats. no analogical changes were observed after cetaben treatment in the livers of experimental animals. it was also found that both drugs could increase the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. contrary to clofibric acid, cetaben did not increase solubilization of peroxisomal enzymes [2].
References
[1] kovacs, w. ,walter, i., and stangl, h. cetaben-induced changes on the morphology and peroxisomal enzymes in mh1c1 rat hepatoma and hepg2 human hepatoblastoma cells. histochemistry and cell biology 115, 509-519 (2001).
[2] chandoga, j. ,hampl, l.,turecky, l., et al. cetaben is an exceptional type of peroxisome proliferator. international journal of biochemistry 26(5), 679-696 (1994).
CETABEN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9934 | 55 |