Arnolol
- CAS No.
- 87129-71-3
- Chemical Name:
- Arnolol
- Synonyms
- Arnolol;3-Amino-1-[4-(2-methoxyethyl)phenoxy]-3-methylbutan-2-ol;2-Butanol, 3-amino-1-[4-(2-methoxyethyl)phenoxy]-3-methyl-;1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-methyl-butan-2-ol
- CBNumber:
- CB2875769
- Molecular Formula:
- C14H23NO3
- Molecular Weight:
- 253.34
- MDL Number:
- MFCD00868795
- MOL File:
- 87129-71-3.mol
| FDA UNII | 98HS077RUP |
|---|
Arnolol Chemical Properties,Uses,Production
Originator
Arnolol,ZYF Pharm Chemical
Manufacturing Process
2 methods of producing of 1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-
methyl-butan-2-ol:
1). 19.0 g of 1-[4-(2-methoxyethyl)phenoxy]-3-nitro-3-methylbutan-2-ol are
hydrogenated at 60°C and under a pressure of 6 bar in a mixture of 250 ml of
ethanol and 50 ml of glacial acetic acid in the presence of 4.0 g of palladiumon-
charcoal (10% Pd). After the mixture has been filtered and the solvent has
been evaporated off, the residue is rendered alkaline with 2 N NaOH and the mixture is extracted with CH2Cl2. The organic phase is washed with water and
dried with Na2SO4 to give, after evaporation, 15.0 g of the 1-[4-(2-
methoxyethyl)phenoxy]-3-amino-3-methylbutan-2-ol, melting point 120°-
122°C (dec.).
2). 18.3 g of zinc dust are gradually added to 20.0 g of 1-[4-(2-methoxyethyl)
phenoxy]-3-nitro-3-methylbutan-2-ol in 400 ml of ethanol and 60 ml of
concentrated hydrochloric acid at 50°-60°C. The mixture is stirred at this
temperature for 1 h and filtered and the solvent is evaporated off. After 200
ml of 40% strength NaOH have been added, the product is extracted with
methylene chloride. Solvent is distilled and the 1-[4-(2-methoxyethyl)
phenoxy]-3-amino-3-methylbutan-2-ol is produced, melting point 120°-122°C
(dec.).
Therapeutic Function
Beta-adrenergic blocker (ophthalmic)
Arnolol Preparation Products And Raw materials
Raw materials
Preparation Products
Arnolol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19863 | 58 |
| Hubei Nordina Biotechnology Co., Ltd. | 19371278702 | nuodinashengwu@163.com | China | 971 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24648 | 58 |
| Hubei huizepu Pharmaceutical Technology Co., Ltd | 023-19371278 19371278702 | n13164103386@163.com | China | 3277 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 18013972705 | qqyang@aikonchem.com | China | 10238 | 58 |
