아르놀롤

아르놀롤 C화학적 특성, 용도, 생산

Originator

Arnolol,ZYF Pharm Chemical

Manufacturing Process

2 methods of producing of 1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3- methyl-butan-2-ol:
1). 19.0 g of 1-[4-(2-methoxyethyl)phenoxy]-3-nitro-3-methylbutan-2-ol are hydrogenated at 60°C and under a pressure of 6 bar in a mixture of 250 ml of ethanol and 50 ml of glacial acetic acid in the presence of 4.0 g of palladiumon- charcoal (10% Pd). After the mixture has been filtered and the solvent has been evaporated off, the residue is rendered alkaline with 2 N NaOH and the mixture is extracted with CH2Cl2. The organic phase is washed with water and dried with Na2SO4 to give, after evaporation, 15.0 g of the 1-[4-(2- methoxyethyl)phenoxy]-3-amino-3-methylbutan-2-ol, melting point 120°- 122°C (dec.).
2). 18.3 g of zinc dust are gradually added to 20.0 g of 1-[4-(2-methoxyethyl) phenoxy]-3-nitro-3-methylbutan-2-ol in 400 ml of ethanol and 60 ml of concentrated hydrochloric acid at 50°-60°C. The mixture is stirred at this temperature for 1 h and filtered and the solvent is evaporated off. After 200 ml of 40% strength NaOH have been added, the product is extracted with methylene chloride. Solvent is distilled and the 1-[4-(2-methoxyethyl) phenoxy]-3-amino-3-methylbutan-2-ol is produced, melting point 120°-122°C (dec.).

Therapeutic Function

Beta-adrenergic blocker (ophthalmic)

아르놀롤 준비 용품 및 원자재

원자재

준비 용품

아르놀롤 공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19863	58
Hubei Nordina Biotechnology Co., Ltd.	19371278702	nuodinashengwu@163.com	China	971	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58
Hubei huizepu Pharmaceutical Technology Co., Ltd	023-19371278 19371278702	n13164103386@163.com	China	3277	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.	025-66061636 18013972705	qqyang@aikonchem.com	China	10238	58

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