nifurzide
- CAS No.
- 39978-42-2
- Chemical Name:
- nifurzide
- Synonyms
- nifurzide;Ricridene;N'-[3-(5-Nitro-2-furyl)-2-propenylidene]-5-nitro-2-thiophenecarbohydrazide;5-Nitro-2-thiophenecarboxylic acid N'-[3-(5-nitro-2-furyl)-2-propenylidene] hydrazide;2-Thiophenecarboxylic acid, 5-nitro-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
- CBNumber:
- CB2901022
- Molecular Formula:
- C12H8N4O6S
- Molecular Weight:
- 336.28
- MDL Number:
- MFCD00865988
- MOL File:
- 39978-42-2.mol
| Melting point | 235-236° |
|---|---|
| Density | 1.62±0.1 g/cm3(Predicted) |
| pka | 10.31±0.46(Predicted) |
| FDA UNII | Z35R6K4C26 |
| ATC code | A07AX04 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 orally in mice: 3200 mg/kg (Szarvasi, Fontaine, 1972) |
|---|
nifurzide Chemical Properties,Uses,Production
Originator
Ricridene,Anphar,Switz.,1981
Definition
ChEBI: Nifurzide is a member of thiophenes and a C-nitro compound.
Manufacturing Process
(a) Ethyl-5-nitro-2-thiophene carboxylate:
17.4 g (mol/10 = 17.31 g) of 5-nitrothiophene carboxylic acid are dissolved in
85 ml of absolute ethanol. A stream of gaseous hydrochloric acid is caused to
enter the boiling solution to the point of saturation, and for 5 hours.
Evaporation to dryness takes place and then the solid residue is washed with
a sodium bicarbonate solution. It is suction-filtered and washed with water.
After drying, there are obtained 17.7 g of a yellow product with a melting
point of 63°C to 65°C and the yield is 88% (theoretical yield = 88%).
The N'-(5'-nitro-2'-thenoyl)hydrazide is prepared by reacting hydrazine with
ethyl 5-nitro-2-thiophene carboxylate.
(b) 6.3 g (mol/30 = 6.5 g) of N1-[5'-nitro-2'-thenoyl]hydrazide are dissolved
in 100 ml of dry tetrahydrofuran. 5.6 g (mol/30 = 5.55 g) of 5-nitro-2-furyl
acrolein in 56 ml of tetrahydrofuran are added. Heating under reflux takes
place for 1 hour and, 25 minutes after starting the heating, the crystallization
commences; the crystals are suction-filtered, washed with ether and dried.
There are obtained 7.9 g (yield 70%-theoretical yield = 11.2 g) of a yellow
solid of melting point 235°C to 236°C.
Recrystallization (tepid dimethylformamide + ether) leaves the melting point
unchanged.
Therapeutic Function
Antibacterial, Antidiarrheal
nifurzide Preparation Products And Raw materials
nifurzide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |