니푸르자이드
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니푸르자이드 속성
- 녹는점
- 235-236°
- 밀도
- 1.62±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 10.31±0.46(Predicted)
안전
| 독성 | LD50 orally in mice: 3200 mg/kg (Szarvasi, Fontaine, 1972) |
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니푸르자이드 C화학적 특성, 용도, 생산
Originator
Ricridene,Anphar,Switz.,1981Manufacturing Process
(a) Ethyl-5-nitro-2-thiophene carboxylate:17.4 g (mol/10 = 17.31 g) of 5-nitrothiophene carboxylic acid are dissolved in 85 ml of absolute ethanol. A stream of gaseous hydrochloric acid is caused to enter the boiling solution to the point of saturation, and for 5 hours. Evaporation to dryness takes place and then the solid residue is washed with a sodium bicarbonate solution. It is suction-filtered and washed with water. After drying, there are obtained 17.7 g of a yellow product with a melting point of 63°C to 65°C and the yield is 88% (theoretical yield = 88%).
The N'-(5'-nitro-2'-thenoyl)hydrazide is prepared by reacting hydrazine with ethyl 5-nitro-2-thiophene carboxylate.
(b) 6.3 g (mol/30 = 6.5 g) of N1-[5'-nitro-2'-thenoyl]hydrazide are dissolved in 100 ml of dry tetrahydrofuran. 5.6 g (mol/30 = 5.55 g) of 5-nitro-2-furyl acrolein in 56 ml of tetrahydrofuran are added. Heating under reflux takes place for 1 hour and, 25 minutes after starting the heating, the crystallization commences; the crystals are suction-filtered, washed with ether and dried. There are obtained 7.9 g (yield 70%-theoretical yield = 11.2 g) of a yellow solid of melting point 235°C to 236°C.
Recrystallization (tepid dimethylformamide + ether) leaves the melting point unchanged.
Therapeutic Function
Antibacterial, Antidiarrheal니푸르자이드 준비 용품 및 원자재
원자재
준비 용품
니푸르자이드 공급 업체
글로벌( 4)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |