Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)-
- CAS No.
- 2143952-36-5
- Chemical Name:
- Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)-
- Synonyms
- SH-42;Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)-
- CBNumber:
- CB310672692
- Molecular Formula:
- C25H38O4
- Molecular Weight:
- 402.58
- MDL Number:
- MOL File:
- 2143952-36-5.mol
Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Chemical Properties,Uses,Production
Biological Activity
SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24; IC50 = 4.2 nM).1 It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2 , as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2
References
1.Müller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017) 2.K?rner, A., Zhou, E., Müller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019)
Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Preparation Products And Raw materials
Raw materials
Preparation Products
Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |