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Siccanin

Siccanin Structure
Siccanin structure
CAS No.
22733-60-4
Chemical Name:
Siccanin
Synonyms
Siccanin;Sicanina;Siccanine;NSC 135048;Siccaninum;CS 280, SI 23548;Siccanin USP/EP/BP;Sicanina [inn-spanish];Siccanine [inn-french];1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol
CBNumber:
CB31120733
Molecular Formula:
C22H30O3
Molecular Weight:
342.47
MDL Number:
MFCD32269323
MOL File:
22733-60-4.mol
MSDS File:
SDS
Last updated:2024-10-23 13:36:13
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Siccanin Properties

Melting point 139-140°
alpha D20 -136° (c = 2 in chloroform)
Boiling point 427.8±45.0 °C(Predicted)
Density 1.18±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form A solid
pka 10.9(at 25℃)
FDA UNII L702S858Z6

SAFETY

Risk and Safety Statements

Toxicity LD50 in mice, rats (mg/kg): >6000, >1000 orally; >3000, >600 s.c. or i.p. (Suzuki)

Siccanin price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23654 Siccanin >98% 22733-60-4 1mg $310 2024-03-01 Buy
Cayman Chemical 23654 Siccanin ≥98% 22733-60-4 5 mg $1082 2024-03-01 Buy
Cayman Chemical 23654 Siccanin >98% 22733-60-4 500μg $168 2022-04-27 Buy
TRC S497055 Siccanin 22733-60-4 1mg $230 2021-12-16 Buy
TRC S497055 Siccanin 22733-60-4 2.5mg $460 2021-12-16 Buy
Product number Packaging Price Buy
23654 1mg $310 Buy
23654 5 mg $1082 Buy
23654 500μg $168 Buy
S497055 1mg $230 Buy
S497055 2.5mg $460 Buy

Siccanin Chemical Properties,Uses,Production

Description

Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively). It inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria. It also inhibits the growth of C. albicans strains with IC50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.

Uses

Siccanin is an antifungal and SDHB (IP) inhibitor.

Uses

Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

Definition

ChEBI: Siccanin is an organic heteropentacyclic compound. It has a role as an antifungal drug and a fungal metabolite.

Origin

Siccanin was found in the culture broth of Helminthosporium siccans by Sankyo Co. in 1962.

Biological Activity

Siccanin shows specific and strong ac tivity against the dermatophytes Trichophyton, Epidermophyton, and Microsporum, but ithas almost no activity against other fungi.

Siccanin Preparation Products And Raw materials

Raw materials

Preparation Products

Siccanin Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 market@aladdin-e.com China 25003 65
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18042 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Lynnchem 86-(0)29-85992781 17792393971 info@lynnchem.com China 4587 58
Novachemistry 44-20819178-90 02081917890 info@novachemistry.com United Kingdom 4381 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
BOC Sciences 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
ChemStrong Scientific Co.,Ltd 56
Shanghai EFE Biological Technology Co., Ltd. 58
Lynnchem 58
Novachemistry 58

View Lastest Price from Siccanin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Siccanin pictures 2024-10-24 Siccanin
22733-60-4
 US $2700.00-775.00 / mg 10g TargetMol Chemicals Inc.
Siccanin USP/EP/BP pictures 2021-07-20 Siccanin USP/EP/BP
22733-60-4
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Siccanin pictures
  • Siccanin
    22733-60-4
  • US $2700.00-775.00 / mg
  • TargetMol Chemicals Inc.

22733-60-4(Siccanin)Related Search:

Cyclohexyl(phenyl)methanol 4-CHROMANOL CHEMBRDG-BB 9070892 (S)-(-)-1-PHENYL-1-DECANOL Siccanin
Siccanin 1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl- (8CI) 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)- (9CI) 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, [4aS-(4aa,6aa,11ba,13aR*,13ba)]- NSC 135048 (13As)-1,2,3,4,4abeta,5,6,6A,11bbeta,13bbeta-decahydro-4,4,6abeta,9-tetramethyl-13H-benzo(A)furo(2,3,4-mn)xanthen-11-ol 13H-Benzo(A)furo(2,3,4-mn)xanthen-11-ol, 1,2,3,4,4A,5,6,6A,11B,13B-decahydro-4,4,6A,9-tetramethyl-, (4as-(4aalpha,6aalpha,11balpha,13ar*,13balpha))- Sicanina Sicanina [inn-spanish] Siccanine Siccanine [inn-french] Siccaninum CS 280, SI 23548 1H,11bH,13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 2,3,4,4a,5,6,6a,13b-octahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)- Siccanin USP/EP/BP 22733-60-4