Imipenem-Cilastatin sodium hydrate
- CAS No.
- 92309-29-0
- Chemical Name:
- Imipenem-Cilastatin sodium hydrate
- Synonyms
- Thienam;Primaxin;Tienam 500;Mk 787-mk 791 mixture;Mk 0787-mk 0791 mixture;85960-17-4 (Hydrochloride salt);Imipenem-Cilastatin sodium hydrate;Imipenem-Cilastatin sodium hydrate USP/EP/BP;IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate;TIANFU-CHEM CAS:92309-29-0 Imipenem-Cilastatin sodium hydrate
- CBNumber:
- CB31261281
- Molecular Formula:
- C28H43N5O9S2
- Molecular Weight:
- 657.8
- MDL Number:
- MOL File:
- 92309-29-0.mol
Imipenem-Cilastatin sodium hydrate Chemical Properties,Uses,Production
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: reduced valproate concentration -
avoid.
Antivirals: convulsions reported with concomitant
administration of ganciclovir and valganciclovir.
Ciclosporin: variable reports of increase / no change
in ciclosporin levels, and of neurotoxicity.
Metabolism
When administered alone, imipenem is metabolised in the kidneys by dehydropeptidase-I, an enzyme in the brush border of the renal tubules, to inactive, nephrotoxic metabolites, with only about 5 to 40 or 45% of a dose excreted in the urine as unchanged active drug. Cilastin inhibits the metabolism of imipenem. When given with cilastatin about 70% of an intravenous dose of imipenem is recovered unchanged in the urine within 10 hours. Cilastatin is also excreted mainly in the urine, the majority as unchanged drug and about 12% as N-acetyl cilastatin. Less than 1% of imipenem is excreted via the bile in the faeces.
Imipenem-Cilastatin sodium hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8853 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5989 | 58 |
SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 23053 | 58 |
View Lastest Price from Imipenem-Cilastatin sodium hydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-22 | Imipenem-Cilastatin sodium hydrate
92309-29-0
|
US $0.00 / KG/Tin | 5KG | Imipenem≥400μg/mg,Cilastatin(C16H26N2O5S) ≥400μg/mg;USP | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2019-08-08 | Imipenem-Cilastatin sodium hydrate
92309-29-0
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Imipenem-Cilastatin sodium hydrate
92309-29-0
- US $0.00 / KG/Tin
- Imipenem≥400μg/mg,Cilastatin(C16H26N2O5S) ≥400μg/mg;USP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Imipenem-Cilastatin sodium hydrate
92309-29-0
- US $3.00 / KG
- 99%
- Career Henan Chemical Co