1'-HYDROXYMIDAZOLAM
- CAS No.
- 59468-90-5
- Chemical Name:
- 1'-HYDROXYMIDAZOLAM
- Synonyms
- α-Hydroxymidazolam;ALPHA-HYDROXYMIDAZOLAM;1-Oh-mdz;RO 21-6347;A-HYDROXYMIDAZOLAM;1Hydroxymidazolame;1'-HYDROXYMIDAZOLAM;1-HYDROXY MIDAZOLAM;1'-Hydroxymidazolam;Midazolam Impurity 1
- CBNumber:
- CB3147586
- Molecular Formula:
- C18H13ClFN3O
- Molecular Weight:
- 341.77
- MDL Number:
- MFCD00871458
- MOL File:
- 59468-90-5.mol
- MSDS File:
- SDS
| Melting point | 264-266oC |
|---|---|
| Boiling point | 540.6±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMF: 2 mg/ml; DMSO: 1 mg/ml |
| form | A crystalline solid |
| pka | 13.59±0.10(Predicted) |
| color | white or off-white |
| FDA UNII | E5142BN92Z |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
1'-HYDROXYMIDAZOLAM Chemical Properties,Uses,Production
Description
1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.
Chemical Properties
White Solid
Uses
A metabolite of Midazolam (M343000).
Uses
CYP3A4 metabolite of midazolam
Definition
ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.
1'-HYDROXYMIDAZOLAM Preparation Products And Raw materials
Raw materials
Preparation Products
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