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PROPERICYAZINE

CAS No.
2622-26-6
Chemical Name:
PROPERICYAZINE
Synonyms
ic6002;rp8908;wh7508;6909rp;Aolept;IC 6002;RP 8908;RP 8909;WH 7508;6909 RP
CBNumber:
CB3162774
Molecular Formula:
C21H23N3OS
Molecular Weight:
365.49
MDL Number:
MFCD00210348
MOL File:
2622-26-6.mol
Last updated:2024-11-18 17:01:59

PROPERICYAZINE Properties

Melting point 116-117°
Boiling point 593.4±50.0 °C(Predicted)
Density 1.1198 (rough estimate)
refractive index 1.6740 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.87±0.20(Predicted)
color Light Yellow to Yellow
Water Solubility 38.01mg/L(37 ºC)
CAS DataBase Reference 2622-26-6
FDA UNII 3405M6FD73
ATC code N05AC01

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
RTECS  SN7175000
Toxicity LD50 orally in rats: 395 mg/kg (Schafer)
NFPA 704
0
3 0

PROPERICYAZINE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P287360 Pericyazine 2622-26-6 25mg $185 2021-12-16 Buy
TRC P287360 Pericyazine 2622-26-6 250mg $1455 2021-12-16 Buy
American Custom Chemicals Corporation API0003549 PROPERICYAZINE 95.00% 2622-26-6 2G $2035 2021-12-16 Buy
ChemScene CS-0002963 Pericyazine 99.83% 2622-26-6 5mg $100 2021-12-16 Buy
ChemScene CS-0002963 Pericyazine 99.83% 2622-26-6 10mg $150 2021-12-16 Buy
Product number Packaging Price Buy
P287360 25mg $185 Buy
P287360 250mg $1455 Buy
API0003549 2G $2035 Buy
CS-0002963 5mg $100 Buy
CS-0002963 10mg $150 Buy

PROPERICYAZINE Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Originator

Aolept, Bayer Vital

Uses

Psychotherapeutic phenothiazine. Antipsychotic.

Uses

Spectrophotometric reagent for palladium and ruthenium.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.

Manufacturing Process

2-Cyano-10-(3-methanesulfonyloxypropyl)phenthiazine and 4hydroxypiperidine in toluene were heated under reflux with stirring. The reaction mixture was allowed to cool and water was added. The resulting toluene solution layer was decanted and washed twice with water. The toluene solution was then stirred with 5% hydrochloric acid. The hydrochloride of the desired phenthiazine base precipitated in gummy condition in the aqueous layer. This was decanted and treated with sodium hydroxide (density 1.33). It was then extracted three times with ethyl acetate. The extracts were dried over sodium sulfate, filtered and concentrated in vacuum. A resinous product was obtained. This product was dissolved in a mixture of benzene and cyclohexane and chromatographed on a column containing alumina. The chromatographed product was eluted successively with mixtures of benzene and cyclohexane and then with benzene and finally with a mixture of benzene and ethyl acetate. The eluates were evaporated to yield a crude product. This product was recrystallised from aqueous ethanol (40% water) and yielded 2cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenthiazine as white crystals.

Therapeutic Function

Neuroleptic

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN-, NOx, and SOx. See also NITRILES.

Purification Methods

It recrystallises from a saturated solution in cyclohexane. It is antipsychotic and is a sensitive reagent for Pd, Va, Ru, Rh and Au. [Gowda et al. Anal Chem 55 1816 1983, Anal Chim Acta 154 347 1983, Beilstein 27 III/IV 4110.]

PROPERICYAZINE Preparation Products And Raw materials

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15354 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923 1026@dideu.com China 8670 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 49979 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from PROPERICYAZINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pericyazine pictures 2024-11-18 Pericyazine
2622-26-6
US $38.00-85.00 / mg 99.61% 10g TargetMol Chemicals Inc.
  • Pericyazine pictures
  • Pericyazine
    2622-26-6
  • US $38.00-85.00 / mg
  • 99.61%
  • TargetMol Chemicals Inc.
PROPERICIAZINE PROPERICYAZINE 1-(3-(2-cyano-10-phenothiazinyl)propyl)-4-piperidino f.i.6145 IC 6002 ic6002 Nelactil Nemactil Neulactil Neuleptil Periciazine Periciazinum pericyazine Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]- Piperocyanomazine RP 8908 RP 8909 rp8908 SKF 20,716 skf20,716 WH 7508 wh7508 10-(3-(4-hydroxypiperidino)propyl)-phenothiazine-2-carbonitril 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile 10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]- 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)- 6909 RP 6909rp Aolept Bayer 1409 bayer1409 Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine cyano-3((hydroxy-4piperidyl-1)-3propyl)-10phenothiazine F.I. 6145 10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile Properazine 2.4.5-Trichlorophenylacetate 1g [2622-26-6] 10-[3-(4-Hydroxy-1-piperidinyl)propyl]- Properciazine 4,6-dibromo-2,2-dimethyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxole Propericiazine (Periciazine) Periciazine oxalate salt RP8909,antipsychotic,Dopamine Receptor,Pericyazine,psychosis,adrenolytic,anxiety,anticholinergic,RP-8909,inhibit,Inhibitor,extrapyramidal 2622-26-6 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds AOLEPT