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5-Chloro-2-thiophenecarboxylic Acid

5-Chloro-2-thiophenecarboxylic Acid structure

CAS No.: 24065-33-6

Chemical Name:: 5-Chloro-2-thiophenecarboxylic Acid

Synonyms: 5-Chlorothiophene-2-carboxylic;5-chloro-2-thiophenecarboxylicaci;5-Chlorothiophen-2-carboxylic acid;5-CHLORO-2-THIOPHENECARBOXYLIC ACID;NSC 14776;AKOS B000092;Rivaroxaban F;2-Amino-9-picoline;RARECHEM AL BE 0303;TIMTEC-BB SBB003937

CBNumber:: CB3189269

Molecular Formula:: C5H3ClO2S

Molecular Weight:: 162.59

MDL Number:: MFCD00041426

MOL File:: 24065-33-6.mol

MSDS File:: SDS

Last updated:2024-08-21 22:41:43

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5-Chloro-2-thiophenecarboxylic Acid Properties

Melting point	154-158 °C(lit.)
Boiling point	287.0±20.0 °C(Predicted)
Density	1.466 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.32±0.10(Predicted)
form	Powder
color	Cream-yellow
BRN	118361
InChI	InChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
InChIKey	QZLSBOVWPHXCLT-UHFFFAOYSA-N
SMILES	C1(C(O)=O)SC(Cl)=CC=1
CAS DataBase Reference	24065-33-6(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	XV5SRC3PJ3
NIST Chemistry Reference	5-Chloro-2-thiophenecarboxylic acid(24065-33-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H319

Precautionary statements

P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36-43-36/37/38

Safety Statements

26-36-37/39

WGK Germany

RTECS

XM8400000

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	0
2		0

5-Chloro-2-thiophenecarboxylic Acid price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	633003	5-Chlorothiophene-2-carboxylic acid 97%	24065-33-6	5g	$31.2	2024-03-01	Buy
Sigma-Aldrich	633003	5-Chlorothiophene-2-carboxylic acid 97%	24065-33-6	25g	$36.48	2024-03-01	Buy
TCI Chemical	C1230	5-Chlorothiophene-2-carboxylic Acid >95.0%(GC)(T)	24065-33-6	5g	$17	2024-03-01	Buy
TCI Chemical	C1230	5-Chlorothiophene-2-carboxylic Acid >95.0%(GC)(T)	24065-33-6	25g	$49	2024-03-01	Buy
Alfa Aesar	A15209	5-Chlorothiophene-2-carboxylic acid, 98%	24065-33-6	5g	$29.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
633003	5g	$31.2	Buy
633003	25g	$36.48	Buy
C1230	5g	$17	Buy
C1230	25g	$49	Buy
A15209	5g	$29.65	Buy

5-Chloro-2-thiophenecarboxylic Acid Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powder

Uses

A metabolite of Rivaroxaban (R538000).

Uses

5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:

rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones

Synthesis

The compound 5-chlorothiophene-2-carboxylic acid is a crucial intermediate in the synthesis of rivaroxaban. Due to its significance, numerous researchers have investigated various methods of synthesizing it. The synthesis of this compound involves the utilization of different starting materials, namely, 2-chlorothiophene, 2-chloro-5-bromothiophene, and 5-chloro-2-acetylthiophene, depending on the specific approach employed. undefined

1. This method takes 2-chlorothiophene as an initial raw material, carrying out Friedel-crafts acylation with trichloroacetyl chloride under the action of aluminum trichloride to generate 2-trichloroacetyl-5-chlorothiophene, and then carrying out liquid alkali hydrolysis to obtain a target product.
2. This method reacts 5-chloro-2-bromothiophene with magnesium to generate a Grignard reagent, introducing carbon dioxide for inserting carbonyl and performing acid-base treatment to obtain a product.
3. 5-chloro-2-acetylthiophene is used as a raw material and is oxidized by sodium chlorite and potassium dihydrogen phosphate system to obtain a target compound.

5-Chloro-2-thiophenecarboxylic Acid synthesis

Synthesis of 5-Chloro-2-thiophenecarboxylic Acid from 2-Chloro-5-thiophenecarboxaldehyde

5-Chloro-2-thiophenecarboxylic Acid Preparation Products And Raw materials

Raw materials

2-Chlorothiophene Nitrogen 2,5-Dichlorothiophene Diethyl ether Sulfuric acid

n-Butyllithium Sodium carbonate

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Preparation Products

4-broMo-5-chlorothiophene-2-carboxylic acid 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE 3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE

5-Chloro-2-thiophenecarboxylic Acid Suppliers

Global( 852)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Beijing Mediking Biopharm Co., Ltd	+undefined15901403431	sales01@mediking.cn	China	150	58
Suzhou Nordica Biopharma CO.,LTD	+8618136148818	anna.ran@nordicabio.com	China	299	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5893	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@sdzhonghuimaterial.com	China	983	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019 +86-15383190639	admin@86-ss.com	China	1000	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50

Supplier	Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Beijing Mediking Biopharm Co., Ltd	58
Suzhou Nordica Biopharma CO.,LTD	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Ruihan Technology Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Frapp's ChemicalNFTZ Co., Ltd.	50

View Lastest Price from 5-Chloro-2-thiophenecarboxylic Acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-03	5-Chloro-2-thiophenecarboxylic Acid 24065-33-6	US $999.00-666.00 / ton	1ton	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2024-11-02	5-Chloro-2-thiophenecarboxylic acid 24065-33-6	US $0.00 / g	1g	98.0%	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-01	5-Chloro-2-thiophenecarboxylic Acid 24065-33-6	US $65.00 / kg	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd

5-Chloro-2-thiophenecarboxylic Acid
24065-33-6
US $999.00-666.00 / ton
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

5-Chloro-2-thiophenecarboxylic acid
24065-33-6
US $0.00 / g
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

5-Chloro-2-thiophenecarboxylic Acid
24065-33-6
US $65.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

5-Chloro-2-thiophenecarboxylic Acid Spectrum

5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID(24065-33-6)MS 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID(24065-33-6)¹HNMR 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID(24065-33-6)¹³CNMR 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID(24065-33-6)IR1 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID(24065-33-6)IR2

24065-33-6(5-Chloro-2-thiophenecarboxylic Acid)Related Search:

Rivaroxaban Impurity 43 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-Thiophenecarboxylic acid (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 41 (S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid (S)-(+)-Glycidyl Phthalimide

4-(4-NITROPHENYL)MORPHOLIN-3-ONE Rivaroxaban Impurity 36 2-Chloro-5-thiophenecarboxaldehyde Rivaroxaban Impurity 34 Rivaroxaban iMpurity 5

Rivaroxaban Impurity 38 Rivaroxaban Impurity 44 Rivaroxaban Impurity 48

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5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID AKOS B000092 2-Thiophenecarboxylic acid, 5-chloro- Chlorothiophene-2-carboxy 5-Chlorothiophene-2-carboxylic Acid, 97+% Rivaroxaban Impurity 40 TIMTEC-BB SBB003937 RARECHEM AL BE 0303 5-Chlorothiophene-2-carboxylicacid,98% 2-CHLOROTHIOPHENE-5-FORMIC ACID CHLOROTHIOPHENEDICARBOXYLICACID 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 98% 5- Chlorothiophene-2-carboxilic acid 5-chlorothiophene-2-carboxylic acid(SALTDATA: FREE) Rivaroxaban Intermediate 4 2-Chloro-5-carboxythiophene NSC 14776 ethyl 4-(3-oxoMorpholino) phenylcarbaMate Rivaroxaban Impurity N Rivaroxaban CTCA Impurity Rivaroxaban F orothiophene-2-carboxyL 5-Chlorothiophene-2-carboxylicAcid> Rivaroxaban EP Impurity F Rivaroxaban intermediates，5-Chloro-2-thiophenecarboxylic acid 5-Chlorothiophene-2-Carboxylic Acide 5-Chlorothiophene-2-carboxylic acid (Rivaroxaban impurity) Rivaroxaban Impurity C/ Rivaroxaban CTCA Impurity Rivaroxaban EP Impurity F/Rivaroxaban CTCA Impurity Rivaroxaban Intermediates 5-Chlorothiophene-2-Carboxylic Acid 24065-33-6 2-Amino-9-picoline 5-Chloro-2-carboxylic acid 5-chlorothiophene-2-carboxylic acidc 5-CHLORO-2-THIOPHENECARBOXYLIC ACID 5-chloro-2-thiophenecarboxylicaci 5-Chlorothiophene-2-carboxylic 5-Chlorothiophen-2-carboxylic acid 5-Chlorothiophene-2-Carboxylic acid (CTA) 5-Chloro Thiophene-2-Carboxylic Acid (5-CTC) 5-ChloroThiophene-2-Carboxylic acid [5CTA] 24065-33-6 24069-33-6 C5H2ClO2S Building Blocks Thiophenes Halogenated Heterocycles Heterocyclic Building Blocks Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Sulfur & Selenium Compounds Intermediates Thiophene&Benzothiophene Miscellaneous Halogenated Heterocycles Heterocyclic Building Blocks Thiophenes ThiophenesBuilding Blocks