PIRIPROST POTASSIUM SALT
- CAS No.
- 88851-62-1
- Chemical Name:
- PIRIPROST POTASSIUM SALT
- Synonyms
- U-60257B;U60,257B POTASSIUM SALT;PIRIPROST POTASSIUM SALT;potassium:5-[(4R,5R)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-1-phenyl-5,6-dihydro-4H-cyclopenta[b]pyrrol-2-yl]pentanoate;1,4(R),5(R),6-TETRAHYDRO-5-HYDROXY-4-[(1E,3S)-HYDROXY-1-OCTENYL]-1-PHENYL-CYCLOPENTA[B]PYRROLE-2-PENTANOIC ACID, MONOPOTASSIUM SALT;[4R-[4A(1E,3S*),5B]]-1,4,5,6-TETRAHYDRO-5-HYDROXY-4-(3-HYDROXY-1-OCTENYL)-1-PHENYL-CYCLOPENTA[B]PYRROLE-2-PENTANOIC ACID, POTASSIUM SALT;[4r-[4α(1e,3s*),5β]]-1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, potassium salt;U60,257B, [4R-[4α(1E,3S*),5β]]-1,4,5,6-Tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, potassium salt
- CBNumber:
- CB3199257
- Molecular Formula:
- C26H34KNO4
- Molecular Weight:
- 463.65
- MDL Number:
- MFCD02259346
- MOL File:
- 88851-62-1.mol
| storage temp. | −20°C |
|---|---|
| solubility | ≤43mg/ml in ethanol;30mg/ml in DMSO;8.6mg/ml in dimethyl formamide |
| form | solid |
| FDA UNII | 2ZYM2BH34M |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
PIRIPROST POTASSIUM SALT price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18228 | Piriprost (potassium salt) ≥98% | 88851-62-1 | 1mg | $53 | 2024-03-01 | Buy |
| Cayman Chemical | 18228 | Piriprost (potassium salt) ≥98% | 88851-62-1 | 5mg | $227 | 2024-03-01 | Buy |
| Cayman Chemical | 18228 | Piriprost (potassium salt) ≥98% | 88851-62-1 | 10mg | $399 | 2024-03-01 | Buy |
| Cayman Chemical | 18228 | Piriprost (potassium salt) ≥98% | 88851-62-1 | 50mg | $1740 | 2024-03-01 | Buy |
| TRC | P508803 | PiriprostPotassium | 88851-62-1 | 2.5mg | $135 | 2021-12-16 | Buy |
PIRIPROST POTASSIUM SALT Chemical Properties,Uses,Production
Uses
Piriprost Potassium is a structural analog of prostaglandin I2.
Uses
Antiasthmatic.
Biological Activity
piriprost (u 60257) is a leukotriene synthesis inhibitor [1].leukotrienes belong to a family of eicosanoid inflammatory mediators produced in leukocytes. leukotrienes mainly act on a subfamily of g protein-coupled receptors. the production of leukotrienes is implicated in triggerring contractions in the smooth muscles lining the bronchioles and is a major cause of inflammation in asthma and allergic rhinitis [2].piriprost inhibited the formation of 5-hydroxyeicosatetraenoic acid (5-hete), ltb4, and the sulfidopeptide leukotrienes with the ic50 values ranged from 9 to 14 μm for the mouse mast cells and 15-50 μm for the basophil leukemia cells. piriprost weakly inhibited the solubilized ltc synthase of rat basophil leukemia cells with the ic50 of 1.5 mm [1]. piriprost increased alkaline phosphatase (alp) activity in cultured endometrial stromal cells. piriprost (100 μm) inhibited 5-lipoxygenase activity and decreased 5-hydroxy-eicosatetraenoic acid (a 5-lipoxygenase product) by 53% [3].in smoke-exposed rabbits, pretreatment with piriprost attenuated the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type i alveolar epithelium [4].
References
[1] bach m k, brashler j r, white g j, et al. experiments on the mode of action of piriprost (u-60,257), an inhibitor of leukotriene formation in cloned mouse mast cells and in rat basophil leukemia cells[j]. biochemical pharmacology, 1987, 36(9): 1461-1466.
[2] smith m j h, ford‐hutchinson a w, bray m a. leukotriene b: a potential mediator of inflammation[j]. journal of pharmacy and pharmacology, 1980, 32(1): 517-518.
[3] cejic s s, kennedy t g. examination of the effects of piriprost (u-60,257 b) on alkaline phosphatase activity of rat endometrial stromal cells in vitro[j]. prostaglandins, 1991, 42(2): 179-189.
[4] itten m l, grad r, quan s f, et al. piriprost pretreatment attenuates the smoke-induced increase in 99mtcdtpa lung clearance[j]. experimental lung research, 1990, 16(4): 339-353.
PIRIPROST POTASSIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
PIRIPROST POTASSIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |