1-Methoxy-9H-carbazole-3-carbaldehyde
- CAS No.
- 723-97-7
- Chemical Name:
- 1-Methoxy-9H-carbazole-3-carbaldehyde
- Synonyms
- Murrayanine;1-Methoxy-9H-carbazole-3-carbaldehyde;9H-Carbazole-3-carboxaldehyde, 1-methoxy-
- CBNumber:
- CB32223213
- Molecular Formula:
- C14H11NO2
- Molecular Weight:
- 225.24
- MDL Number:
- MFCD18452404
- MOL File:
- 723-97-7.mol
Melting point | 168°C |
---|---|
Boiling point | 466.4±25.0 °C(Predicted) |
Density | 1.312±0.06 g/cm3(Predicted) |
pka | 16.49±0.30(Predicted) |
FDA UNII | 3NIN8IA768 |
1-Methoxy-9H-carbazole-3-carbaldehyde Chemical Properties,Uses,Production
Description
This simple carbazole alkaloid is found in the stem bark of Mu"aya koenigii Spreng. It is best purified by sublimation of the crude base when it yields colour_x0002_less crystals. The ultraviolet spectrum in ethanol has absorption maxima at 238, 247,274,289 and 335 mJJ.. The structure has been shown to be 3-formyl-lmethoxycarbazole by spectroscopic methods and synthesis. It yields an oxime, m.p. l55-6°C; a picrate, m.p. 198-2000 C and the 2:4-dinitrophenylhydrazone, m.p. > 300°C. The N-methyl derivative forms colourless needles from C6H6- light petroleum, m.p. l48-9°C. When subjected to Wolff-Kishner reduction, the alkaline phase yields l-hydroxy-3-methyl-carbazole.
Uses
Murrayanine is a carbazole alkaloid. Murrayanine suppresses the proliferation and metastasis of human breast cancer cells via induction of apoptosis and inhibition of RANK/RANKL signaling pathway.
Definition
ChEBI: A natural product found in Clausena harmandiana.
References
Chakraborty, Barman, Bose., Tetrahedron, 21, 681 (1965)
Synthesis:
Crum, Sprague., Chern. Cornrnun., 417 (1966)
Chakraborty, Chowdhury., J. Org. Chern., 33, 1265 (1968)
1-Methoxy-9H-carbazole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methoxy-9H-carbazole-3-carbaldehyde Suppliers
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