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(R,R,R)-Aprepitant

(R,R,R)-Aprepitant structure

CAS No.: 1148113-53-4

Chemical Name:: (R,R,R)-Aprepitant

Synonyms: Aprepitant A;(R,R,R)-Aprepitant;(1R,2R,3R)-Aprepitant;"1R,2R,2R Aprepitant";Aprepitant impurity 04;Aprepitant EP Impurity E;Aprepitant Related CoMpound A;Aprepitant trans-1-enantiomer;Aprepitant USP RC A (R,R,R-Diasteromer);Aprepitant EP Impurity E/ (R,R,R)-Aprepitant

CBNumber:: CB32557888

Molecular Formula:: C23H21F7N4O3

Molecular Weight:: 534.43

MDL Number:: MFCD23704633

MOL File:: 1148113-53-4.mol

Last updated:2024-05-08 10:06:06

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(R,R,R)-Aprepitant Properties

Density	1.51±0.1 g/cm3(Predicted)
pka	8.06±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H413-H302
Precautionary statements	P264-P270-P301+P312-P330-P501
HS Code	2934990002

(R,R,R)-Aprepitant price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1041915	Aprepitant Related Compound A United States Pharmacopeia (USP) Reference Standard	1148113-53-4	10MG	$1300	2024-03-01	Buy
TRC	A729785	(R,R,R)-Aprepitant	1148113-53-4	25mg	$5095	2021-12-16	Buy
American Custom Chemicals Corporation	API0027120	APREPITANT RELATED COMPOUND A 95.00%	1148113-53-4	5MG	$504.12	2021-12-16	Buy
AK Scientific	6464EM	(R,R,R)-Aprepitant	1148113-53-4	2mg	$590	2021-12-16	Buy

Product number	Packaging	Price	Buy
1041915	10MG	$1300	Buy
A729785	25mg	$5095	Buy
API0027120	5MG	$504.12	Buy
6464EM	2mg	$590	Buy

(R,R,R)-Aprepitant Chemical Properties,Uses,Production

Uses

(R,R,R)-Aprepitant (Aprepitant EP Impurity E) is the (R,R,R)-enantiomer of Aprepitant (A729800), the key intermediate of Aprepitant in bulk drug and formulation samples of Aprepitant.

Application

(R,R,R)-Aprepitant (Aprepitant Related Compound A) is a USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

(R,R,R)-Aprepitant synthesis

Synthesis of (R,R,R)-Aprepitant from 5-Chloromethyl-2H-1,2,4-triazolin-3-one and (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine

(R,R,R)-Aprepitant Preparation Products And Raw materials

Raw materials

(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 5-Chloromethyl-2H-1,2,4-triazolin-3-one

Preparation Products

(R,R,R)-Aprepitant Suppliers

Global( 74)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11922	58
Moxin Chemicals	+8617320513646	mike@molcoo.com	China	9460	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Finetech Industry Limited	58
CR Corporation Limited	58
sgtlifesciences pvt ltd	58
LEAP CHEM CO., LTD.	58
China National Standard Pharmaceutical Corporation Limited	58
Moxin Chemicals	58
Amadis Chemical Company Limited	58

1148113-53-4((R,R,R)-Aprepitant)Related Search:

Aprepitant Aprepitant Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide) Atorvastatin Ethyl Ester Atorvastatin Related Compound C

Atorvastatin Methyl Ester Atorvastatin Epoxy Tetrahydrofuran IMpurity Atorvastatin Acetonide Atenolol 2-[4-(2,3-DIHYDROXYPROPOXY)PHENYL]ACETAMIDE

Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide Atorvastatin tert-Butyl Ester 2,3-Dehydroxy Atorvastatin Sodium Salt 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt O-Methyl Atorvastatin Calcium Salt

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Aprepitant Impurity 11 HCl Aprepitant Impurity 2

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(R,R,R)-Aprepitant Aprepitant Related Compound A (10 mg) (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one) 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one Aprepitant Related CoMpound A Aprepitant EP Impurity E Aprepitant A Aprepitant USP RC A (R,R,R-Diasteromer) Aprepitant trans-1-enantiomer (1R,2R,3R)-Aprepitant 3-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one Aprepitant impurity 5/Aprepitant EP Impurity E Aripitant related substance A reference substance 3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro- 5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one Aprepitant EP Impurity E/ (R,R,R)-Aprepitant "1R,2R,2R Aprepitant" Aprepitant Related Compound A (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fl (1041915) Aprepitant(R,R,R)-Isomer（Azilsartan Impurity 41） Aprepitant impurity 04 Aprepitant RRR isomer (diastearomer)-(5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl) morpholino)methyl)-1,2-dihydro-1,2,4-triazol-3-one) 1148113-53-4 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals