ChemicalBook >> CAS DataBase List >>R 112 (pharMaceutical)
R 112 (pharMaceutical)
- CAS No.
- 575474-82-7
- Chemical Name:
- R 112 (pharMaceutical)
- Synonyms
- R112, >98%;R-112; R 112;(E)-Elafibranor;R 112 (pharMaceutical);3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit
- CBNumber:
- CB32667633
- Molecular Formula:
- C16H13FN4O2
- Molecular Weight:
- 312.3
- MDL Number:
- MOL File:
- 575474-82-7.mol
- MSDS File:
- SDS
Last updated:2023-09-04 16:42:00
| Boiling point | 552.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.494±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.48±0.10(Predicted) |
| FDA UNII | Y7W5AL9KHB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
R 112 (pharMaceutical) price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22929 | R112 | 575474-82-7 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 22929 | R112 | 575474-82-7 | 5mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 22929 | R112 | 575474-82-7 | 10mg | $593 | 2024-03-01 | Buy |
| Cayman Chemical | 22929 | R112 | 575474-82-7 | 25mg | $1184 | 2024-03-01 | Buy |
| TRC | R060010 | R112 | 575474-82-7 | 5mg | $360 | 2021-12-16 | Buy |
R 112 (pharMaceutical) Chemical Properties,Uses,Production
Description
R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells.
Uses
R 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
R 112 (pharMaceutical) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 53)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13039 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
R 112 (pharMaceutical)
Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-
(E)-Elafibranor
3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol
R-112; R 112
R112, >98%
Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit
3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
575474-82-7