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ChemicalBook >> CAS DataBase List >> R 112 (pharMaceutical)

R 112 (pharMaceutical)

R 112 (pharMaceutical) price.
  • $81 - $1996
  • Product name: R 112 (pharMaceutical)
  • CAS: 575474-82-7
  • MF: C16H13FN4O2
  • MW: 312.3
  • EINECS:
  • MDL Number:
  • Synonyms:R 112 (pharMaceutical);Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;(E)-Elafibranor;3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;R-112; R 112;R112, >98%;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
Price18 Properties Safety Information Description
18 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number4119CR
  • Product descriptionCID9904854
  • Packaging25mg
  • Price$1416
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013741
  • Product description3,3'-[(5-FLUORO-2,4-PYRIMIDINEDIYL)DIIMINO]BIS-PHENOL (R112) 95.00%
  • Packaging5MG
  • Price$495.21
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22929
  • Product descriptionR112
  • Packaging1mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22929
  • Product descriptionR112
  • Packaging5mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22929
  • Product descriptionR112
  • Packaging10mg
  • Price$593
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22929
  • Product descriptionR112
  • Packaging25mg
  • Price$1184
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5235
  • Product descriptionR112 99.95%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5235
  • Product descriptionR112 99.95%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5235
  • Product descriptionR112 99.95%
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5235
  • Product descriptionR112 99.95%
  • Packaging100mg
  • Price$695
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001427
  • Product descriptionR112 98+%
  • Packaging5mg
  • Price$333
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001427
  • Product descriptionR112 98+%
  • Packaging10mg
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001427
  • Product descriptionR112 98+%
  • Packaging25mg
  • Price$839
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001427
  • Product descriptionR112 98+%
  • Packaging50mg
  • Price$1426
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001427
  • Product descriptionR112 98+%
  • Packaging100mg
  • Price$1996
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8657
  • Product descriptionR112 >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4119CR CID9904854 25mg $1416 2021-12-16 Buy
American Custom Chemicals Corporation API0013741 3,3'-[(5-FLUORO-2,4-PYRIMIDINEDIYL)DIIMINO]BIS-PHENOL (R112) 95.00% 5MG $495.21 2021-12-16 Buy
Cayman Chemical 22929 R112 1mg $81 2024-03-01 Buy
Cayman Chemical 22929 R112 5mg $356 2024-03-01 Buy
Cayman Chemical 22929 R112 10mg $593 2024-03-01 Buy
Cayman Chemical 22929 R112 25mg $1184 2024-03-01 Buy
ChemScene CS-5235 R112 99.95% 5mg $90 2021-12-16 Buy
ChemScene CS-5235 R112 99.95% 10mg $150 2021-12-16 Buy
ChemScene CS-5235 R112 99.95% 50mg $450 2021-12-16 Buy
ChemScene CS-5235 R112 99.95% 100mg $695 2021-12-16 Buy
Crysdot CD31001427 R112 98+% 5mg $333 2021-12-16 Buy
Crysdot CD31001427 R112 98+% 10mg $475 2021-12-16 Buy
Crysdot CD31001427 R112 98+% 25mg $839 2021-12-16 Buy
Crysdot CD31001427 R112 98+% 50mg $1426 2021-12-16 Buy
Crysdot CD31001427 R112 98+% 100mg $1996 2021-12-16 Buy
DC Chemicals DC8657 R112 >98% 100mg $450 2021-12-16 Buy
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Properties

Boiling point :552.0±60.0 °C(Predicted)
Density :1.494±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM)
form :A crystalline solid
pka :9.48±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells.

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